Latest Microsatellite instability Stories
The pattern of genomic alterations in colon and rectal tissues is the same regardless of anatomic location or origin within the colon or the rectum, leading researchers to conclude that these two cancer types can be grouped as one.
Mayo Clinic has developed a screening procedure that could dramatically increase testing for Lynch syndrome (http://www.mayoclinic.com/health/lynch-syndrome/DS00669), a hereditary genetic disorder that raises cancer risk, particularly for colorectal cancer.
A class of drugs that shows promise in breast and ovarian cancers with BRCA gene mutations could potentially benefit colorectal cancer patients with a different genetic mutation.
Smoking, an established risk factor for colon cancer, may induce specific epigenetic changes and gene mutations that may be involved in the development of colon cancer.
New research shows for the first time that molecules called microRNA can silence genes that protect the genome from cancer-causing mutations.
Gastric cancer, one of the most common types of cancer, is associated with high mortality rates.
Checkpoint with forkhead and ring finger (CHFR) is a mitotic stress checkpoint gene whose promoter is frequently methylated in various kinds of cancer. In gastric cancer, CHFR promoter hypermethylation has been reported to lead to chromosome instability (CIN) and genetic instability is one of the hallmarks of human cancer.