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Latest Mir-200 Stories

3-way Genetic Switch Revealed For Cancer Metastasis
2013-10-24 09:00:34

Rice University Cancer researchers from Rice University have deciphered the operating principles of a genetic switch that cancer cells use to decide when to metastasize and invade other parts of the body. The study found that the on-off switch's dynamics also allows a third choice that lies somewhere between "on" and "off." The extra setting both explains previously confusing experimental results and opens the door to new avenues of cancer treatment. The study appears online this week...

2013-08-09 10:15:15

A small group of immune-regulating molecules, when overproduced even moderately, can trigger the blood cancers known as lymphomas, according to a new study led by scientists from The Scripps Research Institute (TSRI). The six “microRNA” molecules were already known to be overproduced in lymphomas and in many other human cancers, but no one had demonstrated that they can be the prime cause of such cancers—until now. The new study also identified the major biological pathways through...

2013-02-06 09:47:41

Researchers have identified two molecules that could potentially serve as biomarkers in predicting brain metastases in patients with breast cancer, according to data published in Cancer Research, a publication of the American Association for Cancer Research. Currently, most deaths from breast cancer are a result of metastatic disease. New research shows that cancer stem-like cells – commonly defined as cells within a tumor with the capacity to initiate a new tumor, proliferate...

2012-12-11 15:50:45

Tumor metastasis, the ability of cancer cells to migrate from their tissue of origin and colonize elsewhere in the body, accounts for over 90% of cancer deaths. When patients die from cancer, it is usually caused by distant metastases established by malignant cells that split off from the primary cancer and began growing in new settings. Scientists from the Ludwig Center at the University of Chicago hypothesized over 15 years ago that an intermediate state of tumor spread or metastasis...

2012-11-30 16:09:19

A team of scientists, led by researchers at the University of California, San Diego School of Medicine, has shown for the first time how cancer cells control the ON/OFF switch of a program used by developing embryos to effectively metastasize in vivo, breaking free and spreading to other parts of the body, where they can proliferate and grow into secondary tumors. The findings are published in the December 11 issue of the journal Cancer Cell. In 90 percent of cancer deaths, it is the...

2012-11-22 08:50:29

Reintroducing miR-200c to triple-negative breast cancer cells makes migrating cells self-destruct Epithelial cells are homebodies — they like to attach to things and becoming detached initiates a form of cell suicide known as anoikis (literally "homeless" in Latin). But in order for cancer cells to metastasize they have to leave their homes and to survive while traveling they must resist anoikis — like a third-grader at sleep-away camp. Cancer cells do this by taking a page...

2012-09-27 13:38:03

Researchers at Moffitt Cancer Center have discovered that the micro ribonucleic acid miR-214 plays a critical role in regulating ovarian cancer stem cell properties. This knowledge, said the researchers, could pave the way for a therapeutic target for ovarian cancer. The study appears in a recent issue of the The Journal of Biological Chemistry. According to the study´s lead author, Jin Q. Cheng, Ph.D., M.D., senior member of the Molecular Oncology Department and Molecular Oncology...


Word of the Day
abrosia
  • Wasting away as a result of abstinence from food.
The word 'abrosia' comes from a Greek roots meaning 'not' and 'eating'.