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Last updated on April 19, 2014 at 13:20 EDT

Latest Mitochondrial disease Stories

2012-05-03 19:23:40

Study also highlights shortcomings of current genetic testing methods to prevent certain genetic disorders Research conducted at the Oregon National Primate Research Center at Oregon Health & Science University helps answer some long-standing questions about how certain disease-causing gene mutations are inherited. The research specifically focused on gene mutations in cell mitochondria that can cause several diseases, including forms of cancer, diabetes, infertility and...

2012-04-27 11:28:14

The following research from NewYork-Presbyterian Hospital/ Columbia University Medical Center is being presented at the 64th annual meeting of the American Academy of Neurology (AAN), April 21-26, 2012, in New Orleans. ORAL PRESENTATIONS Dynamic Cerebral Autoregulation Is Transiently Impaired after Large-Vessel Acute Ischemic Stroke Authors: Nils Petersen, Santiago Ortega-Gutierrez, Andres Reccius, Amy Huang, Arjun Masurkar, and Randolph Marshall Background/Significance: Dynamic...

2012-03-21 10:28:57

A collaborative study by scientists at Baylor College of Medicine (BCM) and the Montreal Neurological Institute of McGill University, and published March 20 in the online, open access journal PLoS Biology, has discovered that mutations in the same gene that encodes part of the vital machinery of the mitochondrion can cause neurodegenerative disorders in both fruit flies and humans. Vafa Bayat in Dr. Hugo Bellen's lab at BCM, examined a series of mutant fruit flies for defects leading to...

2012-03-12 15:02:25

Researchers at the UCLA stem cell center and the departments of chemistry and biochemistry and pathology and laboratory medicine have identified, for the first time, a generic way to correct mutations in human mitochondrial DNA by targeting corrective RNAs, a finding with implications for treating a host of mitochondrial diseases. Mutations in the human mitochondrial genome are implicated in neuromuscular diseases, metabolic defects and aging. There currently are no methods to successfully...

2012-01-03 14:30:16

Aging-related tissue degeneration can be caused by mitochondrial dysfunction in tissue stem cells. The research group of Professor Anu Suomalainen Wartiovaara in Helsinki University, with their collaborators in Max Planck Institute for Biology of Aging, Karolinska Institutet and University of Wisconsin reported on the 3rd January in Cell Metabolism their results on mechanisms of aging-associated degeneration. Stem cells are called the spare parts for tissues, as they maintain and repair...

2011-07-28 17:46:56

Max Planck researchers encounter genetic changes in the genome of the cellular power plants of human induced pluripotent stem cells Induced pluripotent stem cells (iPS cells) are truly talented multi-taskers. They can reproduce almost all cell types and thus offer great hope in the fight against diseases like Alzheimer's and Parkinson's. However, it would appear that their use is not entirely without risk: during the reprogramming of body cells into iPS cells, disease-causing mutations can...

2011-06-29 07:00:29

(Ivanhoe Newswire) -- A class of anti-retroviral drugs commonly used to treat HIV, particularly in Africa and low income countries, can cause premature aging, according to this study. The study shows that the drugs damage DNA in the patient's mitochondria "“ the 'batteries' which power their cells. The findings may explain why HIV-infected people treated with antiretroviral drugs sometimes show advanced signs of frailty and age-associated diseases such as cardiovascular disease and...

2011-06-16 09:42:00

OMAHA, Neb., June 16, 2011 /PRNewswire/ -- Transgenomic, Inc. (OTC/BB: TBIO) today announced the launch of the Nuclear Mitome Test, a genetic test to aid physicians in the diagnosis of mitochondrial disorders. The Nuclear Mitome Test, employs next-generation sequencing technology to identify mutations in more than 400 genes, and represents the most comprehensive genetic test available for mitochondrial disorders. The announcement was made at the 2011 United Mitochondrial Disease Foundation...

2011-06-08 02:01:00

MOUNTAIN VIEW, Calif., June 8, 2011 /PRNewswire/ -- Edison Pharmaceuticals, Inc. announced today that the U.S. Food and Drug Administration (FDA) has allowed an Expanded Access program to provide EPI-743 to seriously ill patients diagnosed with inherited respiratory chain diseases of the mitochondria. Patients with genetically confirmed disease and patients who meet specific clinical criteria, absent genetic confirmation are both eligible. As of June 1, 2011, 40 seriously ill subjects...

2011-05-31 13:03:21

Pre-implantation genetic diagnosis (PGD) can give women at risk of passing on a mitochondrial DNA disorder to their offspring a good chance of being able to give birth to an unaffected child, a researcher told the annual conference of the European Society of Human Genetics today (Monday). Dr. Debby Hellebrekers, from Maastricht University Medical Centre, Maastricht, The Netherlands, said that the scientists' findings could have a considerable effect on preventing the transmission of...