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Latest Mitochondrial disease Stories

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2010-04-16 08:22:16

Finds that cells without mitochondrial fusion have less mtDNA, more mutations in their mtDNA, and less ability to tolerate those mutations A typical human cell contains hundreds of mitochondria"”energy-producing organelles"”that continually fuse and divide. Relatively little is known, however, about why mitochondria undergo this behavior. In a paper published in the April 16 issue of the journal Cell, a team of researchers"”led by scientists at the California Institute of...

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2010-04-15 13:25:00

Embryos containing genetic material from a man and two women have been produced in a project that researchers are hailing as a "ray of hope" for thousands of families troubled by rare genetic diseases that can lead to heart failure, blindness, diabetes and even infant mortality. The technique used has researchers hopeful that it could be offered to women within three years. But the study is likely to re-spark the debate over the ethics of embryo research and "designer babies." Women who...

2009-12-17 14:53:00

OMAHA, Neb., Dec. 17 /PRNewswire-FirstCall/ -- Transgenomic, Inc. (OTC Bulletin Board: TBIO) announced today that it has reached agreement with Gene Solutions for an exclusive licensing option to a set of validated mutations found in Parkinson's disease patients that can form the basis of a novel and accurate diagnostic test for Parkinson's disease. Transgenomic's platform mitochondrial mutation detection technology will be evaluated and optimized to develop a diagnostic test that...

2009-10-23 12:08:40

Soon you could be genetically screened for mitochondrial disorders quickly and comprehensively. Research published in BioMed Central's open access journal, Genome Medicine, outlines an innovative clinical diagnostic test for the early identification of a wide range of mitochondrial disorders. Mutations to one of the mitochondrial genes, or to a number of nuclear genes with roles in mitochondrial function, can cause diseases which have very similar symptoms, making them difficult to diagnose...

2009-08-27 22:26:00

WOBURN, Mass., Aug. 27 /PRNewswire/ -- U.S. researchers using CRi's Oosight(TM) imaging system have developed a gene transfer technique that has potential to prevent inherited diseases passed on from mothers to their children through mutated DNA in cell mitochondria. The research, which demonstrated the technique in rhesus monkeys, appears in the Aug. 26 issue of the journal Nature. The group, headed by Dr. Shoukhrat Mitalipov of the Oregon National Primate Research Center and the Oregon...

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2009-08-27 06:20:00

Researchers believe they have found a way to avoid certain genetically inherited disorders through a special kind of in vitro fertilization (IVF).  Ethical concerns abound, but experts say that the future of the procedure looks promising. In lab experiments with rhesus macaque monkeys, scientists from the Oregon Health and Science University were recently able to transfer DNA from the nucleus of an unhealthy egg cell into a normal egg cell without a nucleus, ultimately resulting in the...

2009-08-26 13:29:10

U.S. researchers say they have used implanted donor eggs to prevent the inheritance of a class of mitochondrial disorders in non-human primates. Scientists at the Oregon Health Science University in Beaverton, Ore., said they transferred hereditary material from the egg of a primate mother into a donor female's egg from which the hereditary material had been emptied. The resulting eggs were fertilized with donor sperm and implanted in the mothers, producing offspring having mitochondria only...

2009-08-06 10:35:57

The normal aging process has long been linked to problems with cell respiration, the process through which the cells extract energy from nutrients. Researchers at the Swedish medical university Karolinska Institutet have now shown how certain proteins that are synthesized in the cellular mitochondria "“ popularly known as the cells' power plants "“ become unstable and disintegrate, which in turn can impair cell respiration and cause premature aging.Every time we inhale, the blood...

2009-07-28 11:09:46

Repeated stress signals made in cells with metabolism-associated disease encourage the growth of invading bacteriaMitochondrial diseases disrupt the power generating machinery within cells and increase a person's susceptibility to bacterial infection, particularly in the lungs or respiratory tract. A new study published in Disease Models & Mechanisms (DMM), shows that infection with the pneumonia causing bacteria Legionella, is facilitated by an increased amount of a signaling protein...

2009-06-09 05:15:00

Highly Sensitive Genetic Test Provides Early Diagnosis of Mitochondrial Diseases LOS ANGELES, June 9 /PRNewswire/ -- MEDomics, LLC (www.medomics.com) announces an innovative test for early diagnosis of mitochondrial diseases, a group of disorders that can result in neurological dysfunction, muscle weakness, gastrointestinal symptoms, migraine headaches, blindness, deafness, and diabetes. The MEDomics mitochondrial genome test, MitoDx(TM), uses the revolutionary NextGen sequencing technology...