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Latest Mitochondrial genetics Stories

2012-04-27 11:28:14

The following research from NewYork-Presbyterian Hospital/ Columbia University Medical Center is being presented at the 64th annual meeting of the American Academy of Neurology (AAN), April 21-26, 2012, in New Orleans. ORAL PRESENTATIONS Dynamic Cerebral Autoregulation Is Transiently Impaired after Large-Vessel Acute Ischemic Stroke Authors: Nils Petersen, Santiago Ortega-Gutierrez, Andres Reccius, Amy Huang, Arjun Masurkar, and Randolph Marshall Background/Significance: Dynamic...

2012-04-25 21:23:00

DNA from the heart's own cells plays a role in heart failure by mistakenly activating the body's immune system, according to a study by British and Japanese researchers DNA from the heart's own cells plays a role in heart failure by mistakenly activating the body's immune system, according to a study by British and Japanese researchers, co-funded by the British Heart Foundation (BHF). Scientists from King's College London and Osaka University Medical School in Japan showed that during...

Forensic-Science-Used-To-Determine-Whos-Who-In-Pre-Columbian-Peru.
2012-04-23 04:15:11

Analysis of ancient mitochondrial DNA (mtDNA) has been used to establish migration and population patterns for American indigenous cultures during the time before Christopher Columbus sailed to the Americas. New research published in BioMed Central's open access journal BMC Genetics has used more detailed DNA analysis of individuals from Arequipa region to identify the family relationships and burial traditions of ancient Peru. The social unit (ayllu) of Native South Americans is thought...

2012-03-12 15:02:25

Researchers at the UCLA stem cell center and the departments of chemistry and biochemistry and pathology and laboratory medicine have identified, for the first time, a generic way to correct mutations in human mitochondrial DNA by targeting corrective RNAs, a finding with implications for treating a host of mitochondrial diseases. Mutations in the human mitochondrial genome are implicated in neuromuscular diseases, metabolic defects and aging. There currently are no methods to successfully...

2011-09-06 22:14:55

In Leigh syndrome, infants are born apparently healthy only to develop movement and breathing disorders that worsen over time, often leading to death by the age of 3. The problem is that the mitochondria responsible for powering their cells can't keep up with the demand for energy in their developing brains. Now, researchers reporting in the September issue of Cell Metabolism, a Cell Press publication, have discovered a new genetic defect that can lead to the disease. The findings were...

2011-07-28 17:46:56

Max Planck researchers encounter genetic changes in the genome of the cellular power plants of human induced pluripotent stem cells Induced pluripotent stem cells (iPS cells) are truly talented multi-taskers. They can reproduce almost all cell types and thus offer great hope in the fight against diseases like Alzheimer's and Parkinson's. However, it would appear that their use is not entirely without risk: during the reprogramming of body cells into iPS cells, disease-causing mutations can...

2011-06-29 07:00:29

(Ivanhoe Newswire) -- A class of anti-retroviral drugs commonly used to treat HIV, particularly in Africa and low income countries, can cause premature aging, according to this study. The study shows that the drugs damage DNA in the patient's mitochondria "“ the 'batteries' which power their cells. The findings may explain why HIV-infected people treated with antiretroviral drugs sometimes show advanced signs of frailty and age-associated diseases such as cardiovascular disease and...

2011-06-08 02:01:00

MOUNTAIN VIEW, Calif., June 8, 2011 /PRNewswire/ -- Edison Pharmaceuticals, Inc. announced today that the U.S. Food and Drug Administration (FDA) has allowed an Expanded Access program to provide EPI-743 to seriously ill patients diagnosed with inherited respiratory chain diseases of the mitochondria. Patients with genetically confirmed disease and patients who meet specific clinical criteria, absent genetic confirmation are both eligible. As of June 1, 2011, 40 seriously ill subjects...

2011-06-07 23:01:00

MOUNTAIN VIEW, Calif., June 8, 2011 /PRNewswire/ -- Edison Pharmaceuticals, Inc. announced today the United States Food and Drug Administration has granted orphan drug designation to EPI-743 for treatment of inherited mitochondrial respiratory chain diseases. Today, these mitochondrial diseases affect an estimated 60,000 individuals. The Orphan Drug Act, passed in 1982, provides incentives for companies to pursue treatments for diseases affecting fewer than 200,000 individuals in the...


Word of the Day
snash
  • To talk saucily.
  • Insolent, opprobrious language; impertinent abuse.
This word is Scots in origin and probably imitative.