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Last updated on April 21, 2014 at 1:20 EDT

Latest MLH1 Stories

2011-06-06 13:54:51

Among various genetic mutations for individuals with Lynch syndrome, a hereditary cancer syndrome that carries a high risk of colon cancer and an above-normal risk of other cancers, researchers have identified mutations associated with a lower cancer risk and mutations associated with an increased risk for ovarian and endometrial cancer, according to a study in the June 8 issue of JAMA, a theme issue on cancer. The study is being published early online to coincide with the American Society of...

2010-04-30 12:19:18

New research shows for the first time that molecules called microRNA can silence genes that protect the genome from cancer-causing mutations. The study, led by researchers at the Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, shows that microRNA-155 (miR-155) can inhibit the activity of genes that normally correct the damage when the wrong bases are paired in DNA. The loss or silencing of these genes, which are...