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Latest Molecular genetics Stories

A Novel Double-Stranded DNA Structure Identified
2012-08-03 13:06:37

Researchers' findings address a scientific debate that had lasted for 16 years over the existence of a double-stranded DNA structure Double-stranded DNA has often been described as a right-handed helical structure, known as B-DNA. To perform its multiple functions, double-stranded DNA has multiple structures depending on conditions. For example, the melted DNA bubble forms during transcription elongation and the left-handed helical Z-DNA forms hypothetically during transcriptional...

Library of Genetic Circuits Developed For Scientific Functions
2012-08-03 13:24:55

April Flowers for redOrbit.com - Your Universe Online For about a dozen years, synthetic biologists have been working on designing genetic circuits to perform novel functions such as manufacturing new drugs, producing fuel or even programming the suicide of cancer cells. Many factors have to be controlled for this dream to become a reality. Scientists have to gain control over complex genetic and cellular components, including genes and the regulatory proteins, called transcription...

2012-07-30 12:49:50

Alternating hemiplegia of childhood (AHC) is a very rare disorder that causes paralysis that freezes one side of the body and then the other in devastating bouts that arise at unpredictable intervals. Seizures, learning disabilities and difficulty walking are common among patients with this diagnosis. Researchers at Duke University Medical Center have now discovered that mutations in one gene cause the disease in the majority of patients with a diagnosis of AHC, and because of the root...

2012-06-27 14:24:19

Epigenetic memory may pass RNA silencing from 1 generation to the next Organisms employ a fascinating array of strategies to identify and restrain invasive pieces of foreign DNA, such as those introduced by viruses. For example, many viruses produce double-stranded (ds)RNA during their life cycle and the RNA interference (RNAi) mechanism is thought to recognize this structural feature to initiate a silencing response. Now, UMass Medical School researchers have identified a mechanism...

2012-06-21 23:41:05

Researchers at the Whitehead Institute and Memorial Sloan-Kettering Cancer Center have defined and analyzed the crystal structure of a yeast Argonaute protein bound to RNA. This complex plays a key role in the RNA interference (RNAi) pathway that silences gene expression. Describing the molecular structure of a eukaryotic Argonaute protein has been a goal of the RNAi field for close to a decade. "You can learn a lot from biochemical experiments, but to more fully understand a protein like...

2012-06-20 06:21:34

(Ivanhoe Newswire) — A new study opens doors to understanding prostate cancer with the identification of a potential new pathway in prostate cancer cells by which cancer-driving gene products can be created. "Our work shows that cancers have many more tricks than we thought to generate potential cancer-driving genes or gene products," Hui Li, Ph.D., assistant professor of pathology at the University of Virginia in Charlottesville, and a recipient of an Innovative Research Grant from...

2012-06-04 17:41:18

Pared-down nucleic acid nanoparticle poses less risk of side effects, offers better targeting. Using a technique known as “nucleic acid origami,” chemical engineers have built tiny particles made out of DNA and RNA that can deliver snippets of RNA directly to tumors, turning off genes expressed in cancer cells. To achieve this type of gene shutdown, known as RNA interference, many researchers have tried – with some success – to deliver RNA with particles made...


Word of the Day
caparison
  • A cloth or covering, more or less ornamented, laid over the saddle or furniture of a horse, especially of a sumpter-horse or horse of state.
  • Clothing, especially sumptuous clothing; equipment; outfit.
  • To cover with a caparison, as a horse.
  • To dress sumptuously; adorn with rich dress.
This word ultimately comes from the Medieval Latin 'cappa,' cloak.
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