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Last updated on April 24, 2014 at 1:21 EDT

Latest Molecular neuroscience Stories

2014-04-14 14:20:45

Alzheimer's disease, the primary cause of dementia in the elderly, imposes a tremendous social and economic burden on modern society. In Japan, the burden of the disease in 2050 is estimated to be a half a trillion US dollars, a figure equivalent to the government's annual revenues. Unfortunately, it has proven very difficult to develop drugs capable of ameliorating the disease. After a tremendous burst of progress in the 1990s, the pace of discoveries has slowed. Dr. Saido believes that...

Gordon Supercomputer Helps Guide New Drug Designs
2014-02-19 12:45:35

University of California, San Diego Single amyloid-beta monomers can pair up to form a variety of dimers that can aggregate into larger peptide rings that reside on cell membranes such as those pictured. This process has been implicated in the development of Alzheimer’s disease. This visualization shows the possible rings which have the most favorable energies of interactions with the membrane. The residues are colored white to represent apolar or hydrophobic areas, green for the polar...

Unraveling Mysteries Of Amyloid Beta Peptides To Detect And Treat Alzheimer's Disease
2014-02-18 07:41:38

American Institute of Physics Alzheimer's disease has long been marked by progress -- but not the kind of progress the medical community seeks. It is the most common form of dementia among older Americans, and its risk increases with increasing age; for those living with the disease, its ravages get worse over time; and as we move into the 21st century, it will place a greater and greater burden on society. The number of Americans living with Alzheimer's has doubled since 1980 and is...

2013-12-05 23:40:35

The N-methyl-D-aspartic acid (NMDA) receptor dysfunction in the brain of aged animals has been shown. In older rodents, N-methyl-D-aspartate receptor 2B subunit gene expression declines significantly associated with memory impairment. To further reveal this process, Dr. Chunxia Li and colleagues from East China Normal University, China analyzed gene expression profiles in the neocortex of aged Tg mice. Pathway and signal-net analyses identified multiple pathways altered in the transgenic...

Brain's Long-Term Reward System Relies On Dopamine
2013-08-05 10:15:52

Brett Smith for redOrbit.com - Your Universe Online From driving across country to graduating from college, long-term goals are often difficult to stay focused on when an immediate reward isn't within sight. A team of researchers from the University of Washington in Seattle and MIT has recently discovered new details on how the brain is able to stay focused until these long-term goals are achieved, according to a report in the journal Nature. The joint team's research builds on...

2013-07-26 14:12:08

Study first to use 'structural' approach in hunt for amyloid-inhibiting agents UCLA chemists and molecular biologists have for the first time used a "structure-based" approach to drug design to identify compounds with the potential to delay or treat Alzheimer's disease, and possibly Parkinson's, Lou Gehrig's disease and other degenerative disorders. All of these diseases are marked by harmful, elongated, rope-like structures known as amyloid fibrils, linked protein molecules that form...

Researchers Quantify Brain Protein Changes In Alzheimer Patients
2013-06-13 08:30:44

April Flowers for redOrbit.com - Your Universe Online A significant and potentially pivotal difference between the brains of patients with an inherited form of Alzheimer's disease and healthy family members who do not have it has been measured by researchers at Washington University School of Medicine in St. Louis. Researchers have long known that a protein fragment called amyloid beta builds up into plaques in Alzheimer´s patient´s brains. The theory is that these plaques...

2013-05-29 09:48:10

For several years, the pharmaceutical industry has tried to develop drugs that target a specific neurotransmitter receptor in the brain, the NMDA receptor. This receptor is present on almost every neuron in the human brain and is involved in learning and memory. NMDA receptors also have been implicated in several neurological and psychiatric conditions such as Alzheimer's disease, Parkinson's disease, schizophrenia and depression. But drug companies have had little success developing...

2013-05-22 12:30:34

Funds to Advance Research Across Key Tau Programs in Alzheimer's disease NEW YORK, May 22, 2013 /PRNewswire/ -- Oligomerix, Inc., a privately held company pioneering the development of disease modifying therapeutics for Alzheimer's disease (AD) and related neurodegenerative disorders, announced today the completion of its Series B financing, which includes both issuance of new convertible preferred shares and warrants that would represent approximately $2.8M in new investments in...

2013-03-20 23:02:27

Dr. J G Moellendorf, DC, ND, LCP reports on recent research at the University of Leeds (United Kingdom) finding that natural polyphenols in green tea and red wine disrupt a primary step in the development of Alzheimer´s disease. Sturgeon Bay, WI (PRWEB) March 20, 2013 Many genetic and environmental risk factors have been pointed to as causing Alzheimer´s disease. An estimated 14 million baby boomers (born between 1946 and 1964) are expected to develop Alzheimer´s and other...