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Latest Molecular neuroscience Stories

2011-10-03 13:22:38

New approach simplifies the search for more specific drugs Psychiatric ailments such as depression, obsessive-compulsive disorder or anxiety states are often associated with disturbances in the metabolism of the neurotransmitter serotonin. Neurotransmitters are compounds that are released from the synapses at nerve cell endings and activate the firing of neighboring neurons. Thus, as their name suggests, they mediate the transmission of nerve impulses. The serotonin transporter (SERT) is...

2011-09-29 09:24:18

Nicolas G. Bazan, MD, Ph.D, Boyd Professor and Director of the Neuroscience Center of Excellence at LSU Health Sciences Center New Orleans, and David Stark, an MD/Ph.D student working in his lab, have discovered how a key chemical neurotransmitter that interacts with two receptors in the brain promotes either normal function or a disease process -- determining whether brain cells live or die. The work is published and highlighted in the September 28, 2011 issue of the Journal of Neuroscience....

2011-08-17 12:16:52

Findings could be used to develop treatments to protect other nerve cell types responsible for speech and movement Neuroscientists have identified a natural protection mechanism in some of the brain's nerve cells during the onset of stroke. The findings, published today [17 August] in the Journal of Neuroscience, could be used to develop treatments to protect other nerve cell types responsible for speech and movement. Stroke "” the third largest cause of death in the UK "” causes...

2011-08-10 22:41:10

Researchers studying mice are getting closer to understanding how stress affects mood and motivation for drugs. According to the researchers, blocking the stress cascade in brain cells may help reduce the effects of stress, which can include anxiety, depression and the pursuit of addictive drugs. A research team from St. Louis and Seattle reports in the Aug. 11 issue of the journal Neuron that in mice exposed to stress, a protein called p38ÃŽ± mitogen-activated protein...

2011-06-16 13:21:10

Precisely mapped allosteric binding site will facilitate design of drugs with minimal side effects Structural biologists at Cold Spring Harbor Laboratory (CSHL) have obtained a precise molecular map of the binding site for an allosteric inhibitor in a subtype of the NMDA (N-methyl-D-aspartate) receptor, which is commonly expressed in brain cells. The newly discovered binding site -- a docking port within the receptor -- is important because it is a potential target for drugs that can modulate...

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2011-04-28 09:03:23

A new study reveals a novel gene associated with major depression. The research, published by Cell Press in the April 28 issue of the journal Neuron, suggests a previously unrecognized mechanism for major depression and may guide future therapeutic strategies for this debilitating mood disorder. Major depression is a psychiatric disorder that is responsible for a substantial loss in work productivity and can even lead to suicide in some individuals. "Current treatments for major depression...

2011-04-26 23:32:16

Structure of GluN2D subunit when docked with certain neurotransmitters helps explain the receptor's slow deactivation Structural biologists at Cold Spring Harbor Laboratory (CSHL) in collaboration with colleagues at Emory University have determined the molecular structure of a key portion, or subunit, of a receptor type commonly expressed in brain cells. The receptor is one of several NMDA (N-methyl-D-aspartate) receptor variants, and the subunit in question is that which specifically binds...

2011-04-25 12:49:35

By shedding new light on how cells migrate in the developing brain, researchers at Fred Hutchinson Cancer Research Center also may have found a new mechanism by which other types of cells, including cancer cells, travel within the body. The findings by Jonathan Cooper, Ph.D., member and director of the Hutchinson Center's Basic Sciences Division, and Yves Jossin, Ph.D., a research fellow in Cooper's laboratory, published online April 24 in Nature Neuroscience, could lead to a better...

2011-04-08 15:25:08

Researchers from the CHUM Research Centre (CRCHUM) have identified a new gene that predisposes people to both autism and epilepsy. Led by the neurologist Dr. Patrick Cossette, the research team found a severe mutation of the synapsin gene (SYN1) in all members of a large French-Canadian family suffering from epilepsy, including individuals also suffering from autism. This study also includes an analysis of two cohorts of individuals from Quebec, which made it possible to identify other...

2011-03-03 12:56:48

A new study provides fascinating insight into the genetic basis of bipolar disorder, a highly heritable mood disorder characterized by recurrent episodes of mania and depression. The research, published by Cell Press online February 24 in the American Journal of Human Genetics, identifies a previously unrecognized susceptibility factor for bipolar disorder. Genome-wide association studies (GWAS) provide a way to systematically sort through all the DNA of many individuals in order to identify...


Word of the Day
holluschickie
  • A 'bachelor seal'; a young male seal which is prevented from mating by its herd's older males (mated bulls defending their territory).
This comes from the Russian word for 'bachelors.'
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