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Latest Molecular neuroscience Stories

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2010-03-22 07:31:28

The brains of males and females, and how they use them, may be far more different than previously thought, at least in the fruit fly Drosophila melanogaster, according to research funded by the Wellcome Trust. In a paper published today in the journal Nature Neuroscience, researchers from the University of Glasgow and the University of Oxford, have shown that the gene known as 'doublesex' (dsx), which determines the shape and structure of the male and female body in the fruit fly, also...

2010-01-27 16:21:21

Scientists at the Brain Research Centre and Centre for Molecular Medicine and Therapeutics have uncovered a key cellular mechanism that alters brain cell function in Huntington's disease, and identified a possible treatment for the disease. The results of the study were published online today and will appear in the January 28 edition of the journal Neuron. Huntington's disease is an inherited degenerative brain disease that causes cognitive and motor impairment, and eventually death. One in...

2010-01-21 20:34:05

For the first time, research led by Youming Lu, PhD, MD, Professor of Neurology and Neuroscience at LSU Health Sciences Center New Orleans School of Medicine, has identified a novel mechanism that may trigger brain damage during stroke and identified a therapeutic approach to block it. The work, funded by the National Institute on Aging (NIA) and the National Institute of Neurological Disorders and Stroke (NINDS), both of the National Institutes of Health (NIH), as well as the American Heart...

2010-01-21 17:01:08

Biomedical scientists from the University of Central Florida and Louisiana State University have identified a way to block a "cell death signal" that they believe triggers brain damage during strokes. Strokes, also known as cerebral ischemia, are caused by inadequate blood flow to the brain and are the third-leading cause of death in the United States. The team's work focused on a neurotransmitter that typically plays an important role in communication among nerve cells in the brain and...

2010-01-11 13:35:20

Blocking the function of an enzyme in the brain with a specific kind of vitamin E can prevent nerve cells from dying after a stroke, new research suggests. In a study using mouse brain cells, scientists found that the tocotrienol form of vitamin E, an alternative to the popular drugstore supplement, stopped the enzyme from releasing fatty acids that eventually kill neurons. The Ohio State University researchers have been studying how this form of vitamin E protects the brain in animal and...

2009-12-16 06:45:00

EVANSTON, Ill., Dec. 16 /PRNewswire/ -- Naurex Inc., a new clinical stage company developing innovative treatments for depression and other CNS disorders based on its novel GFPA NMDA receptor modulators, today announced that it has initiated a Phase I clinical trial of its lead compound GLYX-13 and has successfully dosed the first subjects in the study. GLYX-13, a glycine site functional partial agonist (GFPA) selective modulator of the NMDA receptor, is initially being developed as a...

2009-11-15 13:02:14

Better understanding of synaptic activity may support 'use it or lose it' hypothesis Investigators at Burnham Institute for Medical Research (Burnham), the University of British Columbia's Centre for Molecular Medicine and Therapeutics and the University of California, San Diego have found that normal synaptic activity in nerve cells (the electrical activity in the brain that allows nerve cells to communicate with one another) protects the brain from the misfolded proteins associated with...

2009-11-12 11:34:00

A domain of the NR2B subunit of the NMDA receptor is mapped in exquisite detail A team of scientists at Cold Spring Harbor Laboratory (CSHL) reports on Thursday their success in solving the molecular structure of a key portion of a cellular receptor implicated in Alzheimer's, Parkinson's, and other serious illnesses. Assistant Professor Hiro Furukawa, Ph.D., and colleagues at CSHL, in cooperation with the National Synchrotron Light Source at Brookhaven National Laboratory, obtained crystal...

2009-10-30 23:52:49

Scientists discover lipid may be vital to learning Saturated fats have a deservedly bad reputation, but Johns Hopkins scientists have discovered that a sticky lipid occurring naturally at high levels in the brain may help us memorize grandma's recipe for cinnamon buns, as well as recall how, decades ago, she served them up steaming from the oven. The Hopkins team, reporting Oct. 29 in Neuron, reveals how palmitate, a fatty acid, marks certain brain proteins "“ NMDA receptors "“...

2009-10-22 13:34:58

Studies by researchers at Wake Forest University School of Medicine have shown that blocking the NMDA receptor in immature rats leads to profound, rapid brain injury and disruption of auditory function as the animals mature. The N-methyl-D-aspartate (NMDA) receptor is activated when a chemical in the brain called glutamate is released by brain cells. This allows calcium to enter into these cells, which can then influence a wide array of important functions. By blocking the receptor, calcium...