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Last updated on April 21, 2014 at 12:45 EDT

Latest MSH2 Stories

2013-08-19 10:33:22

Researchers at Michigan State University use TACC supercomputers to understand DNA bending and repair mechanisms The biological information that makes us unique is encoded in our DNA. DNA damage is a natural biological occurrence that happens every time cells divide and multiply. External factors such as overexposure to sunlight can also damage DNA. Understanding how the human body recognizes damaged DNA and initiates repair fascinates Michael Feig, professor of biochemistry and...

2011-09-26 09:16:00

St. Jude Children's Research Hospital scientists tie low levels of a key DNA repair protein to loss of regulatory genes in a study that offers new clues about why acute lymphoblastic leukemia sometimes returns MEMPHIS, Tenn., Sept. 26, 2011 /PRNewswire-USNewswire/ -- A newly identified defect in a DNA repair system might leave some young leukemia patients less likely to benefit from a key chemotherapy drug, possibly putting them at greater risk of relapse. The problem was identified in a...

2011-06-06 13:54:51

Among various genetic mutations for individuals with Lynch syndrome, a hereditary cancer syndrome that carries a high risk of colon cancer and an above-normal risk of other cancers, researchers have identified mutations associated with a lower cancer risk and mutations associated with an increased risk for ovarian and endometrial cancer, according to a study in the June 8 issue of JAMA, a theme issue on cancer. The study is being published early online to coincide with the American Society of...

2005-10-03 15:03:03

ROCHESTER, Minn. -- Mayo Clinic researchers have discovered the inner workings of a defective DNA repair process and are first to explain why certain mutations are not corrected in cells. The finding is important because genetic instability and accumulations of mutations lead to disease. This discovery may lead to ways of fixing the process to avoid Huntington's disease and some types of colon cancer. The Mayo team discovered that under certain conditions, a key protein fails to recognize a...