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Latest Multiprotein complex Stories

Nanocage Builds Itself From Engineered Components
2014-06-06 03:03:25

By Leila Gray, University of Washington A route for constructing protein nanomachines engineered for specific applications may be closer to reality. Biological systems produce an incredible array of self-assembling, functional protein tools. Some examples of these nanoscale protein materials are scaffolds to anchor cellular activities, molecular motors to drive physiological events, and capsules for delivering viruses into host cells. Scientists inspired by these sophisticated...

2014-04-01 14:28:49

Experts analyze baker's yeast to discover potential for combating neurological conditions like Parkinson's and even cancer A humble ingredient of bread – baker's yeast – has provided scientists with remarkable new insights into understanding basic processes likely involved in diseases such as Parkinson's and cancer. In a new study published today (Monday March 31) in the prestigious journal PNAS (Proceedings of the National Academy of Science), the team from Germany, Leicester, and...

2013-10-24 10:23:58

A protein safeguards against cataracts The refractive power of the human eye lens relies on a densely packed mixture of proteins. Special protective proteins ensure that these proteins do not clump together as time passes. When this protective mechanism fails, the ocular lens becomes clouded – the patient develops a cataract. Scientists at the Technische Universitaet Muenchen (TUM) have now resolved the activation mechanism of one of these protective proteins, laying the foundation for...

2013-07-08 12:09:26

UConn researchers shed new light on how cellular transport systems harness energy to perform their work inside the cell Using highly sensitive fluorescent probes, a team of scientists from the University of Connecticut has captured the never-before-seen structural dynamics of an important protein channel inside the cell's primary power plant – the mitochondrion. The UConn team's study found that the channel complex - known as the translocase of the inner mitochondrial...

2013-04-26 14:11:20

Proteins, unlike diamonds, aren't forever. And when they wear out, they need to be degraded in the cell back into amino acids, where they will be recycled into new proteins. Researchers at Rockefeller University and the Howard Hughes Medical Institute have identified a new way that the cell's protein recycler, the proteasome, takes care of unwanted and potentially toxic proteins, a finding that has implications for treating muscle wasting, neurodegeneration and cancer. The consensus among...

Tiny Living Machines Self-assemble
2012-06-11 07:44:26

Insight may help the development of methods to treat diseases at the nanoscale Enabling bioengineers to design new molecular machines for nanotechnology applications is one of the possible outcomes of a study by University of Montreal researchers that was published in Nature Structural and Molecular Biology today. The scientists have developed a new approach to visualize how proteins assemble, which may also significantly aid our understanding of diseases such as Alzheimer's and...

2012-03-06 23:52:44

A new semi-automated tool called pathwalking makes it possible to generate a "first draft" model of a protein fold taken from near-atomic resolution images of between three and six angstroms (Ã…), said researchers at the National Center for Macromolecular Imaging in the department of biochemistry at Baylor College of Medicine. In a report that appears online in the journal Structure, the BCM team describes the development of the semi-automated protocol that enables researchers...

2012-03-06 23:07:50

A new semi-automated tool called pathwalking makes it possible to generate a "first draft" model of a protein fold taken from near-atomic resolution images of between three and six angstroms (Ã…), said researchers at the National Center for Macromolecular Imaging in the department of biochemistry at Baylor College of Medicine. In a report that appears online in the journal Structure, the BCM team describes the development of the semi-automated protocol that enables researchers...

2011-12-21 22:47:54

A team led by a University of Miami researcher is creating the first map of protein interactions within neurons, in a live organism University of Miami biology professor Akira Chiba is leading a multidisciplinary team to develop the first systematic survey of protein interactions within brain cells. The team is aiming to reconstruct genome-wide in situ protein-protein interaction networks (isPIN) within the neurons of a multicellular organism. Preliminary data were presented at the...

2011-04-18 13:27:07

Whether you're talking about genes, or neurons, or the workings of a virus, at the most fundamental level, biology is a matter of proteins. So understanding what protein complexes look like and how they operate is the key to figuring out what makes cells tick. By harnessing the unique properties of polarized light, Rockefeller scientists have now developed a new technique that can help deduce the orientation of specific proteins within the cell. By turning their instruments toward the nuclear...


Word of the Day
bibliopole
  • A bookseller; now, especially, a dealer in rare and curious books.
This word comes from a Greek phrase meaning 'book seller.'
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