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Latest muscle atrophy Stories

2012-04-11 14:59:04

An abnormally low level of a protein in certain nerve cells is linked to movement problems that characterize the deadly childhood disorder spinal muscular atrophy, new research in animals suggests. Spinal muscular atrophy, or SMA, is caused when a child´s motor neurons — nerve cells that send signals from the spinal cord to muscles — produce insufficient amounts of what is called survival motor neuron protein, or SMN. This causes motor neurons to die, leading to muscle...

2011-11-15 09:41:46

Scientist identify signaling system in the brain responsible for involuntary loss of muscle mass; drugs that regulate this system are already in development Patients with cancer, heart disease and other chronic illness struggle not only with complications inherent to their disease, they also experience an involuntary loss of weight and muscle mass triggered by the body's natural response to infection and inflammation. Increasing nutrition intake does not mitigate the process and there is...

2011-08-02 19:54:25

There is a reason exercise becomes more difficult with age. A report in the August Cell Metabolism, a Cell Press publication, ties the weakness of aging to leaky calcium channels inside muscle cells. But there is some good news: the researchers say a drug already in Phase II clinical trials for the treatment of heart failure might plug those leaks. Earlier studies by the research team led by Andrew Marks of Columbia University showed the same leaks underlie the weakness and fatigue that come...

2011-03-22 21:32:17

Inhibiting a growth factor called myostatin in mice with chronic kidney disease halted the muscle wasting common in the disorder and even reduced inflammation, indicating a new strategy for treating muscle wasting, said researchers from Baylor College of Medicine in a report in The FASEB Journal. "Preventing muscle wasting would be helpful because studies show that people who have lost muscle mass are more likely to suffer disability and death," said Dr. William Mitch, professor of medicine...

2011-01-19 08:00:00

NEW YORK and AUSTIN, Texas, Jan. 19, 2011 /PRNewswire/ -- The Spinal Muscular Atrophy (SMA) Foundation and Rules-Based Medicine, Inc. (RBM) announced today that they have reached the first milestone in a program to develop a panel of plasma protein biomarkers for SMA using RBM's Multi-Analyte Profiling (MAP) technology platform. In this collaboration, RBM will discover and also confirm plasma protein biomarker candidates previously identified from the multicenter Biomarkers for SMA...

2010-12-15 06:00:00

WALTHAM, Mass., Dec. 15, 2010 /PRNewswire/ -- Repligen Corporation (Nasdaq: RGEN) today announced that the Company has received $1,400,000 in research funding from the Muscular Dystrophy Association ("MDA") to support the ongoing development of RG3039 for Spinal Muscular Atrophy ("SMA"). RG3039, our lead compound, is an inhibitor of an RNA processing enzyme which targets increased production of SMN, a protein of deficient levels in patients with SMA. The goal of this grant is to support...

2010-06-10 13:09:40

Children who suffer from the devastating disease Spinal Muscular Atrophy are set to benefit from a new breakthrough in therapy developments by researchers at the University of Sheffield. The research, which was published yesterday (9 June 2010) in Science Translational Medicine, has shown that a novel gene transfer system has the potential to provide an effective therapeutic treatment for SMA patients. SMA is a devastating motor neuron disease which affects children. It is caused by an...

2010-05-18 11:49:22

Neuromuscular electrical stimulation (NMES) may reduce muscle atrophy in patients with severe chronic obstructive pulmonary disease (COPD), according to Canadian researchers. The results were reported at the ATS 2010 International Conference in New Orleans. NMES is the application of electrical stimulation to a group of muscles through electrodes placed on the skin. It is primarily used by physical therapists to help restore function to injured muscles. Isabelle Vivodtzev, Ph.D. and...

2010-03-13 08:16:44

Changes in muscle cell structure can affect gene expression New findings that shed light on how genetic damage to muscle cell proteins can lead to the development of the rare muscle-wasting disease, nemaline myopathy, are reported March 15 in the Biochemical Journal. Professor Laura Machesky and colleagues from the CRUK Beatson Institute for Cancer Research in Glasgow, tested cultures of muscle cells that displayed mutations of the ACTA1 gene to determine how the mutations affected the...

2009-12-01 14:29:14

In order to maintain muscle strength with age, cells must rid themselves of the garbage that accumulates in them over time, just as it does in any household, according to a new study in the December issue of Cell Metabolism, a Cell Press journal. In the case of cells, that waste material includes spent organelles, toxic clumps of proteins, and pathogens. The researchers made their discovery by studying mice that were deficient for a gene required for the tightly controlled process of...


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ramage
  • Boughs or branches.
  • Warbling of birds in trees.
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