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Latest muscle atrophy Stories

2009-06-08 11:36:41

During desperate times, such as fasting, or muscle wasting that afflicts cancer or AIDS patients, the body cannibalizes itself, atrophying and breaking down skeletal muscle proteins to liberate amino acids. In a new study published online June 8 and in the June 15, 2009 print issue of the Journal of Cell Biology (www.jcb.org), Shenhav Cohen, Alfred Goldberg, and colleagues show that muscle atrophy is a more ordered process than was previously thought. These researchers find evidence that...

2009-02-27 08:10:07

Newly-published research from the University of Calgary suggests that muscle in obese people and Type 2 diabetes may be conspiring against them Research by kinesiology investigator Dustin Hittel, PhD, has proven that muscle in extremely obese individuals produces large amounts of a protein called myostatin, which normally inhibits muscle growth"”suggesting that for Type 2 diabetics, and the very obese, the task of getting healthy may be more difficult than initially thought. It has been...

2008-10-13 06:00:18

GTx, Inc. (NASDAQ: GTXI) today announced topline results of a Phase II clinical trial evaluating Ostarine(TM) (MK-2866), an investigational selective androgen receptor modulator (SARM), in patients with cancer induced muscle loss, also known as cancer cachexia. In this analysis, the study met its primary endpoint of absolute change in total lean body mass (muscle) compared to placebo and the secondary endpoint of muscle function (performance) after 16 weeks of treatment. GTx and Merck &...

2008-10-08 18:00:34

Families of Spinal Muscular Atrophy (FSMA, www.curesma.org), Invitrogen Corporation (NASDAQ:IVGN)(www.invitrogen.com), and deCODE chemistry & biostructures (www.decodechembio.com) announced today they have identified a protein that is a potential molecular target for the treatment of Spinal Muscular Atrophy (SMA). In its most severe form, SMA often leads to death in infancy, and there is currently no treatment or cure. Research published today in the journal ACS Chemical Biology of the...

2008-09-10 12:00:51

BOSTON, Sept. 10 /PRNewswire-USNewswire/ -- The U.S. National Institutes of Health (NIH) have awarded $9 million to launch a unique collaboration of researchers, clinicians, patients, government research agencies and pharmaceutical/biomedical companies to study the causes and potential treatments for facioscapulohumeral muscular dystrophy (FSHD), a muscle weakening and disabling disease that affects, at the least, one in 20,000 individuals worldwide. The award will create the first Senator...

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2008-04-30 08:56:26

New study in the FASEB Journal identifies c-FLIP and calpain-3 proteins as drug targets in limb-girdle muscular dystrophy and other conditionsA team of French and German researchers report in the May 2008 print issue of The FASEB Journal that people with limb-girdle muscular dystrophy are missing a protein called c-FLIP, which the body uses to prevent the loss of muscle tissue. By targeting the cellular and molecular mechanisms responsible for creating this protein, scientists could develop...

2007-08-24 06:13:50

By Mallette, Paige Zhao, Meijuan; Zurakowski, David; Ring, David Purpose: This study was designed to test the hypothesis that patients with an initial diagnosis of cubital tunnel syndrome are more likely to present with muscle atrophy than patients with an initial diagnosis of carpal tunnel syndrome. Methods: A list of patients presenting to the office of a single hand surgeon from January 2000 to June 2005 with an initial diagnosis of isolated, idiopathic carpal tunnel syndrome or cubital...

2005-11-14 12:31:52

A new study provides important insight into the mechanisms of a muscle wasting disorder that interferes with treatment for cancer and has a negative impact on patient survival. The research, published in the November issue of Cancer Cell, describes an unexpected link between muscular dystrophy and muscle wasting associated with cancer, and suggests a potential strategy for development of therapies to combat cancer-associated muscle wasting. Muscle wasting, or cachexia, is a severe and...

2005-07-14 16:35:00

Dr. Stephen Burden and colleagues demonstrate that the DNA-binding protein, Runx1 (AML1), directs the expression of 29 genes involved in the prevention of skeletal muscle wasting. Using mice deficient in runx1 specifically in skeletal muscle cells, the researchers determined that Runx1 activation is necessary to sustain muscle by limiting the autophagy of denervated myofibers. Dr. Burden believes that their findings "raise the intriguing possibility that congenital myopathies, which do not...

2004-11-29 15:00:12

A pain reliever taken off the U.S. market because of its toxic side effects may be a new treatment for a life-threatening childhood muscle-wasting disease. Ohio State University researchers Monday said indoprofen, a member of the non-steroidal anti-inflammatory drug class that also includes ibuprofen and naproxen, could be part of a future treatment for spinal muscular atrophy. Researchers said the drug increases production of a protein crucial to the survival of nerve cells affected by...