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Latest Mutated citrullinated Vimentin Stories

2012-06-08 13:10:25

Smoking status is not a contributing factor A new study presented today at EULAR 2012, the Annual Congress of the European League Against Rheumatism, shows that lung changes in association with anti-citrullinated protein autoantibody (ACPA) status are a primary manifestation of rheumatoid arthritis (RA). Study findings show that 51% of RA patients (n=105) had identifiable lung changes (as measured by high resolution computer tomography [HRCT]) as compared to 28% of healthy controls...

2012-01-27 11:19:44

Rheumatoid arthritis (RA) is a chronic inflammatory disease where the body begins to attack the joints and organs of the body. Proteins within inflamed joints are often modified by citrullination, a process that converts the protein building block arginine into citrulline. These two amino acids have very different physical properties and consequently conversion can result in aberrant changes in the three-dimensional structure of an affected protein. New research published in BioMed Central's...

2009-06-16 13:40:00

Researchers in France suggest that the season in which rheumatoid arthritis symptoms appear may indicate the severity of those symptoms. The findings, presented in Copenhagen at the annual congress of the European League Against Rheumatism, may help identify patients with rheumatoid arthritis needing more intensive early therapy. Study leader Dr. Gael Mouterde of Lapeyronie Hospital in Montpellier, France, said patients whose first symptoms occur in winter had greater erosion and joint...

2009-06-12 10:22:12

When a patient's first symptoms of rheumatoid arthritis (RA) occur in winter, the severity of their RA (as measured by the modified Total Sharp Score, mTSS, an assessment of erosion and joint space narrowing) was rated more severe at six months, when compared to patients whose RA first became symptomatic in summer (Odds Ratio (OR) =2.82 [1.14;7], p=0.0255). Furthermore, RA patients with their first symptoms in spring showed poorer radiographic outcome compared to summer-onset patients...

2009-04-06 03:28:00

BANGKOK, April 6 /PRNewswire/ -- Rheumatoid arthritis (RA) is a systemic disease or an autoimmune disorder in which the body's defense system attacks the joints through the thin layer of cells called the synovium that lines and lubricates the joints. The most visible symptoms of RA are swollen joints and crippling stiffness, particularly of the hands and feet. It can cause fatigue, fever, loss of appetite and also impedes mobility and quality of life. RA cannot be confirmed or excluded by one...

2008-10-24 09:00:26

Cypress Bioscience, Inc. (NASDAQ: CYPB) will launch its first two novel personalized medicine services at the American College of Rheumatology Annual Scientific Meeting in San Francisco on October 24-29, 2008. The initial personalized medicine services facilitate improved diagnostic, prognostic and therapeutic decision making for rheumatologists treating patients with rheumatoid arthritis (RA). Avise PG(SM) is a test that supports dose optimization and therapeutic decision making for...

2006-08-30 14:35:17

By David Douglas NEW YORK (Reuters Health) - The production of antibodies to certain foods is "strikingly increased" in the gut of many patients with rheumatoid arthritis, Norwegian researchers report. It may be that hypersensitivity to certain foods leads to a flare-up in the joints. Dr. Per Brandtzaeg of Rikshospitalet, Oslo and colleagues note that people with rheumatoid arthritis often feel there is an association between food intake and disease severity. He told Reuters Health...