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Latest Mutation Stories

2014-08-20 16:25:38

New approach complements whole-genome and whole-exome sequencing BOSTON, Aug. 20, 2014 /PRNewswire-USNewswire/ -- Not every cell in the body is the same genetically, and disease-causing mutations don't necessarily affect every cell--making these mutations easy to miss even with next-generation genomic sequencing. A study from Boston Children's Hospital used a "deep sequencing" technique and was able to identify subtle somatic mutations--those affecting just a percentage of cells--in...

New Mechanism Of Drug Resistance Discovered By Scientists
2014-07-29 03:47:02

Marla Vacek Broadfoot, Duke University Microorganisms like bacteria and fungi can evade treatment by acquiring mutations in the genes targeted by antibiotics or antifungal drugs. These permanent mutations were once thought to be the only way for drug-resistant strains to evolve. Now a new study has shown that microorganisms can use a temporary silencing of drug targets -- known as epimutations -- to gain the benefits of drug resistance without the commitment. Though the new mechanism...

2014-07-10 12:45:13

Salk Institute New results ease previous concerns that gene-editing techniques—used to develop therapies for genetic diseases—could add unwanted mutations to stem cells. The ability to switch out one gene for another in a line of living stem cells has only crossed from science fiction to reality within this decade. As with any new technology, it brings with it both promise—the hope of fixing disease-causing genes in humans, for example—as well as questions and safety concerns....

2014-07-08 14:45:18

Virginia Tech Virginia Tech researchers discover which genetic changes pass the test of extremely different ecologies Scientists have long puzzled over the genetic differences between fruit flies that live hardly a puddle jump apart in a natural environment known as "Evolution Canyon" in Mount Carmel, Israel. Now, an international team of researchers led by scientists with the Virginia Bioinformatics Institute at Virginia Tech has peered into the DNA of these closely related flies...

2014-06-30 08:30:32

SOUTH PLAINFIELD, N.J., June 30, 2014 /PRNewswire/ -- PTC Therapeutics, Inc. (NASDAQ: PTCT) today announced the initiation of a global confirmatory Phase 3 clinical trial of Translarna(TM) (ataluren), an investigational new drug, in patients with nonsense mutation cystic fibrosis (nmCF). Nonsense mutations within cystic fibrosis are categorized as Class I mutations, a severe form of CF that results in little or no production of the CFTR protein. The Phase 3 confirmatory trial is...

2014-06-09 14:30:56

University of North Carolina Health Care The discovery, from the lab of Brian Strahl, Ph.D., offers insights for the creation of better, more targeted therapies for various forms of cancer Twelve years ago, UNC School of Medicine researcher Brian Strahl, PhD, found that a protein called Set2 plays a role in how yeast genes are expressed – specifically how DNA gets transcribed into messenger RNA. Now his lab has found that Set2 is also a major player in DNA repair, a complicated and...

2014-06-06 10:00:13

University of Utah University of Utah researchers find that multiple silent mutations greatly impact protein translation So-called silent DNA mutations earned their title because, according to the fundamental rules of biology, they should be inconsequential. Reported on June 5 in PLOS Genetics online, University of Utah researchers experimentally proved there are frequent exceptions to the rule. The work was conducted in the bacteria, Salmonella enterica, used to study basic biological...

2014-06-03 13:06:47

Duke University Medical Center A collaborative effort between Duke Medicine researchers and neurosurgeons and scientists in China has produced new genetic insights into a rare and deadly form of childhood and young adult brain cancer called brainstem glioma. The researchers identified a genetic mutation in the tumor cells that plays a role in both the growth and the death of a cell. Additionally, the mutation to the newly identified gene may also contribute to the tumor's resistance to...

2014-06-03 12:27:34

Institute of Cancer Research Around a quarter of smokers who carry a defect in the BRCA2 gene will develop lung cancer at some point in their lifetime, a large-scale, international study reveals. Scientists announce a previously unknown link between lung cancer and a particular BRCA2 defect, occurring in around 2 per cent of the population, in research published in Nature Genetics today (Sunday). The defect in BRCA2 - best known for its role in breast cancer - increases the risk of...

blond hair genetics
2014-06-02 05:07:21

redOrbit Staff & Wire Reports - Your Universe Online A subtle alternation in DNA involving one single-letter change in the genetic code is enough to generate blond hair in men and women, researchers from Howard Hughes Medical Institute and the Stanford University Medical Center report in Sunday’s edition of the journal Nature Genetics. According to developmental biology professor Dr. David Kingsley and his colleagues, a molecule essential to stem cell function plays a vital role...


Word of the Day
cacodemon
  • An evil spirit; a devil.
  • A nightmare.
  • In astrology, the twelfth house of a scheme or figure of the heavens: so called from its signifying dreadful things, such as secret enemies, great losses, imprisonment, etc.
'Cacodemon' comes from a Greek term meaning 'evil genius.'
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