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Latest Mutation Stories

2012-04-16 22:16:52

Evolutionary biologists at the University of Toronto have found that individuals with low-quality genes may produce offspring with even more inferior chromosomes, possibly leading to the extinction of certain species over generations. A study published in Proceedings of the National Academy of Sciences (PNAS) predicts that organisms with such genetic deficiencies could experience an increased number of mutations in their DNA, relative to individuals with high-quality genes. The research...

2012-04-11 22:19:20

Scientists have discovered a mutation limited to brain tissue that causes hemimegalencephaly (HMG), a condition where one half of the brain is enlarged and dysfunctional, leading to intellectual disability and severe epilepsy. The research, published by Cell Press in the April 12 issue of Neuron, has broad significance as a potential model for other complex neuropsychiatric diseases that may also be caused by "brain-only" mutations. Mutations can be inherited or occur spontaneously....

2012-04-05 09:35:52

Non-inherited mutations spotlight role of environment — NIH-supported study, consortium Researchers have turned up a new clue to the workings of a possible environmental factor in autism spectrum disorders (ASDs): fathers were four times more likely than mothers to transmit tiny, spontaneous mutations to their children with the disorders. Moreover, the number of such transmitted genetic glitches increased with paternal age. The discovery may help to explain earlier evidence linking...

2012-04-04 10:52:28

Genetic mutations in cancer cells can lead to resistance to treatment, thereby potentially resulting in relapse. However, a new article, published April 3 in the magazine section of the online, open-access journal PLoS Biology, suggests that the converse may also happen. Steven Frank from the University of California, Irvine, and Marsha Rosner from the University of Chicago, propose that it may often be the case that a few cells become resistant before any genetic change, and then later...

2012-04-02 15:21:15

Cardiomyopathy comprises a deterioration of the heart muscle that affects the organ's ability to efficiently pump blood through the body. Previously researchers have tied forms of the disease to the alternative splicing of titin, a giant protein that determines the structure and biomechanical properties of the heart, but the molecular mechanism remained unknown. Professor Michael Gotthardt and Professor Norbert Hübner of the Max Delbrück Center for Molecular...

2012-04-02 12:53:53

A second mutation found in the tumors of patients with BRAF-mutated metastatic melanoma does not contribute to resistance to BRAF inhibitor drugs, a finding that runs counter to what scientists expected to be true. The study by researchers at UCLA's Jonsson Comprehensive Cancer Center found that patients with the mutations in both the MEK1 and BRAF genes respond as well to the inhibitors as patients with the BRAF mutation alone. Another surprising finding is that the MEK1 and BRAF...

800px-Vincent_van_Gogh_-_Sunflowers_(Metropolitan_Museum_of_Art)
2012-03-30 13:01:38

For more than a century, Vincent Van Gogh's series of paintings depicting overly-bushy sunflowers were thought to be the result of his alleged mental illness at work, but now could actually be realistic impressions of a genetic mutation seen in some strains of the flowers, according to a new study. Most typical sunflowers have a brown, seed-filled middle and a single ring of yellow petals. But some seem overgrown with double rows of petals -- like the "Teddy Bear" variety -- and others...

2012-03-29 23:18:58

In addition to being among his most vibrant and celebrated works, Vincent van Gogh's series of sunflower paintings also depict a mutation whose genetic basis has, until now, been a mystery In addition to being among his most vibrant and celebrated works, Vincent van Gogh's series of sunflower paintings also depict a mutation whose genetic basis has, until now, been a mystery. In a study published in PLoS Genetics, a team of University of Georgia scientists reveal the mutation behind the...

2012-03-29 12:52:35

Mutations in a gene called XRCC2 cause increased breast cancer risk, according to a study published today in the American Journal of Human Genetics. The study looked at families that have a history of the disease but do not have mutations in the currently known breast cancer susceptibility genes. Sean Tavtigian, Ph.D., a Huntsman Cancer Institute (HCI) investigator and associate professor in the Department of Oncological Sciences at the University of Utah (U of U) is one of three...


Word of the Day
bodacious
  • Remarkable; prodigious.
  • Audacious; gutsy.
  • Completely; extremely.
  • Audaciously; boldly.
  • Impressively great in size; enormous; extraordinary.
This word is probably from the dialectal 'boldacious,' a blend of 'bold' and 'audacious.'
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