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Latest Mutation Stories

2014-05-27 23:06:48

Findings to Enhance System That Is Transforming Genetic Research Charlottesville, VA (PRWEB) May 27, 2014 Researchers at the University of Virginia School of Medicine have devised a way to detect unintended side effects of manipulating genes using a revolutionary new system that is sweeping the scientific world by storm. The gene targeting system, called CRISPR, allows editing of genetic information at specifically targeted sites in the genome. UVA’s new approach reveals the system has...

Genetic Legacy Of A Rare Brain Disorder Traced Back To The Ottoman Empire
2014-04-25 05:17:10

redOrbit Staff & Wire Reports - Your Universe Online Scientists have detected a previously unknown neurodegenerative disorder stemming from a single mutation in one lone individual who lived approximately 16 generations ago during the days of the Ottoman Empire in Turkey, according to two studies appearing in Thursday’s edition of the journal Cell.  [ 1 ] [ 2 ] Two international teams of researchers, each of which was performing DNA sequencing of thousands of Turkish children...

Rainbow Trout Genome Sequenced By International Team Of Researchers
2014-04-22 14:58:22

By Eric Sorensen, Washington State University Using fish bred at Washington State University, an international team of researchers has mapped the genetic profile of the rainbow trout, a versatile salmonid whose relatively recent genetic history opens a window into how vertebrates evolve. The 30-person team, led by Yann Guiguen of the French National Institute for Agricultural Research, reports its findings this week in Nature Communications. Recent doubling enables study The...

2014-04-18 11:32:58

Researchers at UC Davis have identified a new feature of the genetic mutation responsible for the progressive neurodegenerative disorder, fragile X-associated tremor/ataxia syndrome (FXTAS) — the formation of "R-loops," which they believe may be associated with the disorder's neurological symptoms, such as tremors, lack of balance, features of Parkinsonism, and cognitive decline. The finding suggests that the R-loops may be potential targets for drug development, said Paul Hagerman,...

2014-04-14 14:24:06

Genetic evidence supports role of gene family in cancer development Researchers have found a major piece of genetic evidence that confirms the role of a group of virus-fighting genes in cancer development. Our understanding of the biological processes that cause cancer is limited. UV light and smoking are two well-understood cancer-causing processes. Exposure to either of these processes causes distinguishable patterns of genetic damage, or 'signatures', on the genome that can lead to...

2014-04-04 12:23:54

These genes could explain why some women with high-risk mutations suffer from cancer while others do not Today we know that women carrying BCRA1 and BCRA2 gene mutations have a 43% to 88% risk of developing from breast cancer before the age of 70. Taking critical decisions such as opting for preventive surgery when the risk bracket is so wide is not easy. Spanish National Cancer Research Centre (CNIO) researchers are conducting a study that will contribute towards giving every woman far...

2014-04-01 13:16:37

Ribosomes are essential for life, generating all of the proteins required for cells to grow. Mutations in some of the proteins that make ribosomes cause disorders characterized by bone marrow failure and anemia early in life, followed by elevated cancer risk in middle age. These disorders are generally called "ribosomopathies." How can ribosomopathies first appear as diseases caused by too few cells, but later turn into diseases caused by too many cells? This paradox has puzzled the...

2014-02-07 13:01:17

Researchers from North Carolina State University have found a link between a mutation in a gene called RAB 24 and an inherited neurodegenerative disease in Old English sheepdogs and Gordon setters. The findings may help further understanding of neurodegenerative diseases and identify new treatments for both canine and human sufferers. Hereditary ataxias are an important group of inherited neurodegenerative diseases in people. This group of diseases is the third most common...

2014-01-27 15:13:00

Researchers from the University of Southern Denmark have identified how a mutated protein can lead to holes in a protein sitting in a cell's membrane. Such holes cause high blood pressure, and the discovery can now lead to new and better medication for high blood pressure. High blood pressure can be caused by many things - one of them being a specific mutated protein. Now the researchers at University of Southern Denmark have found out exactly what unfortunate events in the human organism...

2014-01-27 13:30:39

A simple adjustment to a powerful gene-editing tool may be able to improve its specificity. In a report receiving advance online publication in Nature Biotechnology, Massachusetts General Hospital (MGH) investigators describe how adjusting the length of the the guide RNA (gRNA) component of the synthetic enzymes called CRISPR-Cas RNA-guided nucleases (RGNs) can substantially reduce the occurrence of DNA mutations at sites other than the intended target, a limitation the team had previously...


Word of the Day
mundungus
  • A stinking tobacco.
  • Offal; waste animal product; organic matter unfit for consumption.
This word comes from the Spanish 'mondongo,' tripe, entrails.