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Latest Mutation Stories

2012-11-20 11:47:58

Certain mutated cells keep trying to replicate their DNA – with disastrous results – even after medications rob them of the raw materials to do so, according to new research from USC. New imaging techniques allowed scientists to see for the first time that while chemotherapy drugs shut down the DNA replication process of most cancer cells, so-called "checkpoint mutants" just keep chugging along, unwinding the DNA and creating damaged DNA strands that can result in the kind of...

2012-11-01 23:19:01

Researchers find that gene related to germ cell formation is far older than first thought Harvard scientists have solved the long-standing mystery of how some insects form the germ cells — the cellular precursors to the eggs and sperm necessary for sexual reproduction — and the answer is shedding new light on the evolutionary origins of a gene that had long been thought to be critical to the process. As described in a November 1 paper published in Current Biology, a team of...

Genetic Analysis Shows Reasons Behind Selkirk Rex Curly Hair
2012-10-31 04:52:21

April Flowers for redOrbit.com - Your Universe Online Appearance plays a large part in choosing a mate, whether that is your human spouse or your animal pet. Many human societies place a high value on curly hair for appearance — as generations of perm-offering hair dressers can attest. It should be no surprise that pet owners and breeders are attracted to curly haired animals more frequently. Three curly-haired varieties have been recognized and developed into competitive breeds...

Evolution Follows A Predictable Genetic Pattern Researchers Find
2012-10-26 10:20:03

Evolution, often perceived as a series of random changes, might in fact be driven by a simple and repeated genetic solution to an environmental pressure that a broad range of species happen to share, according to new research. Princeton University research published in the journal Science suggests that knowledge of a species' genes – and how certain external conditions affect the proteins encoded by those genes – could be used to determine a predictable evolutionary pattern...

2012-10-23 10:18:13

Like job-seekers searching for a new position, living things sometimes have to pick up a new skill if they are going to succeed. Researchers from the University of California, Davis, and Uppsala University, Sweden, have shown for the first time how living organisms do this. The observation, published Oct. 19 in the journal Science, closes an important gap in the theory of natural selection. Scientists have long wondered how living things evolve new functions from a limited set of genes....

2012-10-17 07:26:15

RICHMOND, Calif., Oct. 17, 2012 /PRNewswire/ -- Sangamo BioSciences, Inc. (Nasdaq: SGMO) announced that data from its program with Shire AG (LSE: SHP, NASDAQ: SHPG) to develop a novel ZFP Therapeutic approach to Huntington's disease (HD), an inherited progressive neurodegenerative disease, were presented at the 2012 Annual Meeting of the Society for Neuroscience, which is the world's largest forum for neuroscientists and is being held in New Orleans from October 13-17, 2012. The data...

2012-10-11 12:57:01

Experimental studies of ancestral visual pigments and their mutational variants cast doubt on simplifying assumptions widely used in evolutionary studies of proteins A key assumption that biologists have relied on widely over the past quarter-century in studying the evolution of protein molecules is "highly questionable," according to an article published in the November issue of BioScience. The article, by Shozo Yokoyama, a vision researcher at Emory University, summarizes experimental...

Chaperone Protein Subverts Removal Of Glaucoma-causing Protein
2012-10-09 15:53:46

Inhibiting the protein, Grp94, could offer new treatment for the sight-robbing eye disease The chaperone protein Grp94 can interfere with the clearance of another protein known to cause the glaucoma when mutated, a new study led by researchers at the University of South Florida has found. Using a cell model, the researchers also demonstrated that a new specific inhibitor of Grp94 facilitates clearance of the genetically-defective protein, called myocilin, from cells. Reported online...

2012-10-04 10:35:06

Milk consumption has been linked to improved health, with decreased risks of diabetes, metabolic syndrome, and colon cancer. A group of scientists in Sweden found that lactoferricin4-14 (Lfcin4-14), a milk protein with known health effects, significantly reduces the growth rate of colon cancer cells over time by prolonging the period of the cell cycle before chromosomes are replicated. In a new study, investigators report that treatment with Lfcin4-14 reduced DNA damage in colon cancer cells...

2012-09-17 14:12:31

A Chinese research team, led by Anhui Medical University and BGI, has found the strong genetic evidences of mevalonate kinase gene (MVK) mutations link to disseminated superficial actinic porokeratosis (DSAP). It is a major step toward discovering the genetic pathogenesis of DSAP, and sheds an eye-opening insight into its further molecular diagnosis and treatment. The latest study was published online in Nature Genetics. DSAP is a rare, non-cancerous, non-contagious skin disorder that...