Latest Myeloproliferative disease Stories
NEW YORK, Sept. 20, 2012 /PRNewswire/ -- National nonprofit CancerCare, along with the advocacy associations that comprise the MPN Coalition, recognizes today as the first ever national Myelofibrosis Awareness Day. This day of recognition serves as the commencement of activities designed to create awareness of myelofibrosis (MF). The theme of the day, Elements of Empowerment, encourages those affected by MF to become knowledgeable about the disease; be partners in their...
MPN Research Foundation and The Leukemia & Lymphoma Society Partner to Fund Concept Grants Chicago, IL & White Plains, NY (PRWEB) July 11, 2012 The MPN Research Foundation and the Leukemia & Lymphoma Society are proud to announce the winners of the MF Challenge. Winners of these one year concept grants focusing on fibrosis and myelofibrosis are: Ann Mullaly & Benjamin L. Ebert, of Brigham & Women’s Hospital Amit Verma and Zhizhuang Joe Zhao, of the Albert...
SEATTLE and SINGAPORE, April 19, 2012 /PRNewswire/ -- Cell Therapeutics, Inc.("CTI") (Nasdaq and MTA: CTIC) and S*BIO Pte Ltd announced today that the companies have entered into an asset purchase agreement pursuant to which CTI would acquire world-wide rights to S*BIO's pacritinib, a highly selective JAK2 inhibitor. Pacritinib is an oral JAK2 (Janus Associated Kinase 2) selective inhibitor that has demonstrated encouraging clinical benefit in phase 1 and 2 clinical studies in...
Ruxolitinib shrinks swollen spleens, eases debilitating symptoms of incurable malignancy A drug that relieves the severe symptoms of a life-threatening bone marrow cancer called myelofibrosis also improves the survival of patients with the disease, according to a phase III clinical trial published in the March 1 edition of New England Journal of Medicine. "The Phase I/II clinical trial showed that ruxolitinib improves quality of life for many patients with myelofibrosis and now this...
Walter and Eliza Hall Institute scientists have revealed new details about how cell signalling is controlled in the immune system, identifying in the process potential new therapeutic targets for treating severe blood disorders. Dr Jeff Babon and Professor Nick Nicola, from the institute's Structural Biology and Cancer and Haematology divisions respectively, study interactions between internal cell signalling proteins called JAKs (Janus kinases) and SOCS (Suppressors of Cytokine...
- Significant and durable responses in anemia, splenomegaly and constitutional symptoms reported - - Well tolerated for dosing periods up to and exceeding two years - - MRI results confirm meaningful improvements in splenomegaly - MISSISSAUGA, ON, Dec. 12, 2011 /PRNewswire/ - YM BioSciences Inc. (NYSE Amex: YMI, TSX: YM), today reported updated results from the ongoing Phase I/II study of its JAK1/JAK2 inhibitor, CYT387, for the treatment of myelofibrosis. The results are being...
SINGAPORE, Dec. 12, 2011 /PRNewswire/ -- S*BIO Pte Ltd today announced that results from a Phase 2 study demonstrated that its JAK2 inhibitor pacritinib (SB1518) effectively reduced splenomegaly in myelofibrosis (MF) patients, with minimal impact on existing cytopenias providing an important therapeutic niche in the treatment of MF. Results were presented at the 53rd ASH Annual Meeting and Exposition in San Diego. "Pacritinib is an active drug for the treatment of...
SAN DIEGO, Dec. 12, 2011 /PRNewswire/ -- Eli Lilly and Company (NYSE: LLY) announced data from an oncology pipeline molecule today at the 53rd Annual Meeting of the American Society of Hematology (ASH). At the meeting, Lilly Oncology presented Phase I data from the investigational therapy LY2784544, a small-molecule Janus kinase 2 (JAK2) inhibitor, in development for the treatment of certain types of myeloproliferative neoplasms (MPNs), a group of blood cancers[1] characterized by...
SINGAPORE, Nov. 22, 2011 /PRNewswire/ -- S*BIO Pte Ltd today announced that data from Phase 2 studies for its JAK2 inhibitor pacritinib (SB1518) and histone deacetylase inhibitor pracinostat (SB939) demonstrate promising activity in patients with myelofibrosis (MF). Results will be presented at the 53rd ASH Annual Meeting and Exposition in San Diego, Calif. "Pacritinib has been well tolerated and has shown activity in alleviating MF-associated splenomegaly and...
MISSISSAUGA, ON, Nov. 7, 2011 /PRNewswire/ - YM BioSciences Inc. (NYSE Amex: YMI, TSX: YM), today announced it would report updated results from its Phase I/II myelofibrosis study of CYT387, a JAK1/JAK2 inhibitor, in a poster session to be held from 6:00pm - 8:00pm on Monday, December 12th at the 53rd Annual Meeting of the American Society of Hematology (ASH) being held in San Diego, California. The Company also reported updated results today from the study that were included in an...
