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Latest NADPH oxidase Stories

2012-06-21 22:57:55

Drugs target Nox2 enzyme directly instead of acting as antioxidants Scientists at Emory University School of Medicine have identified a new type of anti-inflammatory compound that may be useful in treating a wide range of conditions, including neurodegenerative and autoimmune diseases. These compounds inhibit the enzyme Nox2, part of a family of enzymes responsible for producing reactive oxygen species (ROS). "Nox2 inhibitors could be valuable with many conditions where inflammation...

2011-10-03 15:42:06

Researchers funded by the Biotechnology and Biological Sciences Research Council (BBSRC), among others, have identified an important cog in the molecular machinery of plant immunity - a discovery that could help crop breeders produce disease-resistant varieties to help ensure future food security. There may also be implications for treating human immune-related disorders. The research, led by Professor Gary Loake at the University of Edinburgh with colleagues from Syngenta is published this...

2010-12-30 13:20:39

NIH study could improve care for chronic granulomatous disease Investigators at the National Institutes of Health have observed that the survival rate of people with a rare immunodeficiency disease called chronic granulomatous disease (CGD) is greatly improved when even very low levels of microbe-killing molecules are present. Because production of these molecules, made by an enzyme called NADPH oxidase, can be predicted from genetic analysis, a patient's risk for severe CGD could be assessed...

2010-10-12 16:39:47

A deficiency in one of the immune system's enzymes affects the severity of autoimmune diseases such as MS, and explains why the course of these diseases can vary so much. New findings give an insight into how this enzyme deficiency can be diagnosed, and could lead to new medicines, reveals a thesis from the Sahlgrenska Academy. Multiple sclerosis (MS) and Guillain-Barr© syndrome (GBS) "“ the two autoimmune diseases covered by the thesis "“ can follow vastly different courses,...

2009-09-16 09:26:05

Researchers at the Burnham Institute for Medical Research (Burnham) have discovered that reactive oxygen species, such as superoxide and hydrogen peroxide, play a key role in forming invadopodia, cellular protrusions implicated in cancer cell migration and tumor metastasis. Sara Courtneidge, Ph.D., professor and director of the Tumor Microenvironment Program at Burnham's NCI-designated Cancer Center, and colleagues have found that inhibiting reactive oxygen reduces invadopodia formation and...

2009-05-05 08:02:43

Obstructive sleep apnea, or periodic interruptions in breathing throughout the night, thickens sufferers' blood vessels.  Moreover, it increases the risk of several forms of heart and vascular disease. Emory researchers have identified the enzyme NADPH oxidase as important for the effects obstructive sleep apnea has on blood vessels in the lung. The results are published in the May 1 issue of the American Journal of Respiratory Cell and Molecular Biology. C. Michael Hart, professor of...

2009-05-04 06:00:00

ATLANTA, May 4 /PRNewswire/ -- Alimera Sciences, Inc., a privately held biopharmaceutical company that specializes in the research, development and commercialization of prescription ophthalmic pharmaceuticals, announced that positive interim 12-month safety and efficacy results from the first human pharmacokinetic study (PK Study) of Iluvien(TM) (fluocinolone acetonide (FA) intravitreal insert) will be presented today at 2:00 p.m. at the Association for Research in Vision and Ophthalmology...


Word of the Day
sough
  • A murmuring sound; a rushing or whistling sound, like that of the wind; a deep sigh.
  • A gentle breeze; a waft; a breath.
  • Any rumor that engages general attention.
  • A cant or whining mode of speaking, especially in preaching or praying; the chant or recitative characteristic of the old Presbyterians in Scotland.
  • To make a rushing, whistling, or sighing sound; emit a hollow murmur; murmur or sigh like the wind.
  • To breathe in or as in sleep.
  • To utter in a whining or monotonous tone.
According to the OED, from the 16th century, this word is 'almost exclusively Scots and northern dialect until adopted in general literary use in the 19th.'
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