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Last updated on April 20, 2014 at 17:20 EDT

Latest Nanopore Stories

2011-06-20 19:50:39

Researchers at Delft University of Technology and the University of Basel have established a biomimetic nanopore that provides a unique test and measurement platform for the way that proteins move into a cell's nucleus. In the journal Nature Nanotechnology (June 19 - online), they report an artificial nanopore that is functionalized with key proteins which mimicks the natural nuclear pore. Upon testing the transport of individual proteins through the biomimetic pore, they found that most...

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2011-05-24 06:21:46

Sequencing DNA base pairs "“ the individual molecules that make up DNA "“ is key for medical researchers working toward personalized medicine. Being able to isolate, study and sequence these DNA molecules would allow scientists to tailor diagnostic testing, therapies and treatments based on each patient's individual genetic makeup. But being able to isolate individual molecules like DNA base pairs, which are just two nanometers across "“ or about 1/50,000th the diameter of a...

2011-04-06 23:18:10

Researchers at Rensselaer Polytechnic Institute Discover New Method To Boost Enzymatic Activity Proteins are critically important to life and the human body. They are also among the most complex molecules in nature, and there is much we still don't know or understand about them. One key challenge is the stability of enzymes, a particular type of protein that speeds up, or catalyzes, chemical reactions. Taken out of their natural environment in the cell or body, enzymes can quickly lose their...

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2011-03-01 09:42:42

By mimicking the structure of the silk moth's antenna, University of Michigan researchers led the development of a better nanopore"”a tiny tunnel-shaped tool that could advance understanding of a class of neurodegenerative diseases that includes Alzheimer's. A paper on the work is newly published online in Nature Nanotechnology. This project is headed by Michael Mayer, an associate professor in the U-M departments of Biomedical Engineering and Chemical Engineering. Also collaborating...

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2010-12-20 11:32:19

Scientists from Imperial College London are developing technology that could ultimately sequence a person's genome in mere minutes, at a fraction of the cost of current commercial techniques. The researchers have patented an early prototype technology that they believe could lead to an ultrafast commercial DNA sequencing tool within ten years. Their work is described in a study published this month in the journal Nano Letters and it is supported by the Wellcome Trust Translational Award and...

2010-12-01 22:54:50

Genome sequencing will have a profound effect on our understanding of genetic biology and could usher in a day when doctor and patient are able to review individual genome sequences to fully personalise medical treatment. As the X PRIZE FOUNDATION begins to receive nominations for its $10m prize for the first privately funded company that can accurately sequence 100 genomes in 10 days for less than $10,000 per genome, the science writer Philip Ball looks at the latest advances towards success...

2010-11-15 13:34:12

The twisting, ladder-like form of the DNA molecule"”the architectural floor plan of life"”contains a universe of information critical to human health. Enormous effort has been invested in deciphering the genetic code, including, most famously, the Human Genome Project. Nevertheless, the process of reading some three-billion nucleotide "letters" to reveal an individual's full genome remains a costly and complex undertaking. Now biophysicist Stuart Lindsay, of the Biodesign...

2010-11-09 20:49:27

Nanopore array allows simultanous tests in search for new drugs Membrane-associated receptors, channels and transporters are among the most important drug targets for the pharmaceutical industry. The search for new drugs resembles looking for a needle in a haystack. Therefore new analytical techniques are required which facilitate the simultaneous screening of a large library of compounds across a variety of membrane proteins. However, this class of methods is still at the early stages of...

2010-09-27 14:25:42

Research demonstrates progress towards DNA strand sequencing Research published this week in Nature Nanotechnology shows a new method of enzyme-controlled movement of a single strand of DNA through a protein nanopore. The paper, by researchers at the University of California Santa Cruz (UCSC), represents a key step towards nanopore sequencing of DNA strands. The publication describes the observation of single stranded DNA (ssDNA) as it translocates through a protein nanopore, alpha hemolysin...

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2010-09-11 12:27:20

Extremely thin membrane, a mere one-atom thick, lives up to its acclaim as a 'rapidly rising star'In a paper published as the cover story of the September 9, 2010 Nature, researchers from Harvard University and MIT have demonstrated that graphene, a surprisingly robust planar sheet of carbon just one-atom thick, can act as an artificial membrane separating two liquid reservoirs.By drilling a tiny pore just a few-nanometers in diameter, called a nanopore, in the graphene membrane, they were...