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Last updated on April 19, 2014 at 8:45 EDT

Latest Nanopore Stories

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2010-08-02 06:46:45

Sandia self-assembly and atomic-layer deposition improve process fivefold In an innovation critical to improved DNA sequencing, a markedly slower transmission of DNA through nanopores has been achieved by a team led by Sandia National Laboratories researchers. Solid-state nanopores sculpted from silicon dioxide are generally straight, tiny tunnels more than a thousand times smaller than the diameter of a human hair. They are used as sensors to detect and characterize DNA, RNA and proteins....

2010-07-30 13:32:21

New theory aids researchers studying DNA, protein transport Polymer strands wriggle their way through nanometer-sized pores in a membrane to get from here to there and do their jobs. New theoretical research by Rice University scientists quantifies precisely how long the journey takes. That's a good thing to know for scientists studying the transport of RNA, DNA and proteins -- all of which count as polymers -- or those who are developing membranes for use in biosensors or as drug-delivery...

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2010-07-27 07:35:48

Researchers at the University of Pennsylvania have developed a new, carbon-based nanoscale platform to electrically detect single DNA molecules. Using electric fields, the tiny DNA strands are pushed through nanoscale-sized, atomically thin pores in a graphene nanopore platform that ultimately may be important for fast electronic sequencing of the four chemical bases of DNA based on their unique electrical signature. The pores, burned into graphene membranes using electron beam technology,...

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2010-07-19 08:54:23

Researchers are developing a new kind of DNA sequencer that will make the dream of "reading" a person's genetic code for less than $1,000 a reality The first human genome took 13 years and $3 billion to sequence. Today, geneticists can generate the same information in a matter of months, for a fraction of the cost. As "next-generation" gene sequencers begin to make their mark on the life sciences, teams around the world are racing to develop new and improved DNA sequencers that can ingest a...

2010-07-14 14:07:30

The movement of long chain polymers through nanopores is a key part of many biological processes, including the transport of RNA, DNA, and proteins. New research reported in The Journal of Chemical Physics, which is published by the American Institute of Physics, describes an improved theoretical model for this type of motion. The new model addresses both cylindrical pores and tapering pores that simulate the ÃŽ±"“hemolysin membrane channel. "Current models do not...

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2010-06-24 10:20:00

National Institute of Standards and Technology (NIST) scientists have moved a step closer to developing the means for a rapid diagnostic blood test that can scan for thousands of disease markers and other chemical indicators of health. The team reports* it has learned how to decode the electrical signals generated by a nanopore"”a "gate" less than 2 nanometers wide in an artificial cell membrane. Nanopores are not new themselves; for more than a decade, scientists have sought to use a...

2010-05-20 15:20:00

Boston University biomedical engineers develop new nanopore method for DNA sequencing Sequencing DNA could get a lot faster and cheaper "“ and thus closer to routine use in clinical diagnostics "“ thanks to a new method developed by a research team based at Boston University. The team has demonstrated the first use of solid state nanopores "” tiny holes in silicon chips that detect DNA molecules as they pass through the pore "” to read the identity of the four...

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2010-04-28 11:20:27

Using a pair of exotic techniques including a molecular-scale version of ice fishing, a team of researchers working at the National Institute of Standards and Technology (NIST) have developed methods to measure accurately the length of "nanopores," the miniscule channels found in cell membranes. The "molecular rulers" they describe in a recent paper* could serve as a way to calibrate tailor-made nanopores"”whose diameters on average are nearly 10,000 times smaller than that of a human...

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2010-01-01 10:50:00

Faster sequencing of DNA holds enormous potential for biology and medicine, particularly for personalized diagnosis and customized treatment based on each individual's genomic makeup. At present however, sequencing technology remains cumbersome and cost prohibitive for most clinical applications, though this may be changing, thanks to a range of innovative new techniques. In the current issue of Science, Stuart Lindsay, director of Arizona State University's Center for Single Molecule...

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2009-12-20 13:15:00

Boston University biomedical engineers have devised a method for making future genome sequencing faster and cheaper by dramatically reducing the amount of DNA required, thus eliminating the expensive, time-consuming and error-prone step of DNA amplification. In a study published in the Dec. 20 online edition of Nature Nanotechnology, a team led by Boston University Biomedical Engineering Associate Professor Amit Meller details pioneering work in detecting DNA molecules as they pass through...