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Last updated on April 20, 2014 at 13:20 EDT

Latest National Academy of Sciences Stories

2013-04-02 12:32:57

Mutations in a protein called SPOP (speckle-type POZ protein) disarm it, allowing another protein called steroid receptor coactivator-3 (SRC-3) to encourage the proliferation and spread of prostate cancer cells, said researchers led by those at Baylor College of Medicine in a report that appears online in Proceedings of the National Academy of Sciences. Normally SPOP acts as a tumor suppressor gene by marking SRC-3 for destruction, said Dr. Nicholas Mitsiades, assistant professor of...

2013-03-26 19:57:42

Solutions that meet the broad, varied, and often competing priorities of conservation are difficult to come by. Research published in the March 28 edition of the Proceedings of the National Academy of Sciences takes a hard look at why, in an effort to find ways to resolve the issue. "People often think of conservation solutions that are effective, cost-efficient, and equitable —— the so-called triple bottom line solutions —— as the holy grail, the best possible...

2013-03-26 12:30:06

-- Genomic, Molecular Findings by CHOP Researchers Will Help Inform Personalized Medicine -- PHILADELPHIA, March 26, 2013 /PRNewswire-USNewswire/ -- Pediatric researchers, investigating the biology of brain tumors in children, are finding that crucial differences in how the same gene is mutated may call for different treatments. A new study offers glimpses into how scientists will be using the ongoing flood of gene-sequencing data to customize treatments based on very specific mutations...

2013-03-26 11:08:01

Osteoarthritis is a painful, debilitating illness affecting more than 27 million people in the US Think new discoveries are the bee's knees? This one is even better -- this research out of Rhode Island Hospital is the mice's knees. Researchers have found that adding lubricin, a protein that our bodies naturally produce, to the fluid in our joints may reduce the risk of or even prevent osteoarthritis (OA). The findings, in a paper by Gregory D. Jay, M.D., Ph.D., of the department of...

2013-03-26 11:05:54

Neurons that control hunger in the central nervous system also regulate immune cell functions, implicating eating behavior as a defense against infections and autoimmune disease development, Yale School of Medicine researchers have found in a new study published in the Proceedings of the National Academy of Sciences (PNAS). Autoimmune diseases have been on a steady rise in the United States. These illnesses develop when the body's immune system turns on itself and begins attacking its own...

2013-03-26 11:03:41

Researchers at the University of California, San Diego Moores Cancer Center have identified a humanized monoclonal antibody that targets and directly kills chronic lymphocytic leukemia (CLL) cells. The findings, published in the online Early Edition of the Proceedings of the National Academy of Sciences on March 25, 2013 represent a potential new therapy for treating at least some patients with CLL, the most common type of blood cancer in the United States. CLL cells express high levels...

2013-03-22 09:42:47

Data about defective regulatory protein described in Proceedings of the National Academy of Sciences A little more than a year after the FDA approved Kalydeco (Vx-770), the first drug of its kind to treat the underlying cause of cystic fibrosis, University of Missouri researchers believe they have found exactly how this drug works and how to improve its effectiveness in the future. Described in the current issue of the Proceedings of the National Academy of Sciences, MU researchers have...

2013-03-19 14:20:06

Potential approach to treating atherosclerosis and other chronic inflammatory diseases A multicenter team of researchers, including scientists at Columbia University Medical Center (CUMC), Brigham and Women's Hospital (BWH), Mount Sinai School of Medicine, and Massachusetts Institute of Technology, has developed biodegradable nanoparticles that are capable of delivering inflammation-resolving drugs to sites of tissue injury. The nanoparticles, which were successfully tested in mice, have...

2013-03-14 19:59:00

Scientist from Dortmund, Helsinki, Potsdam, and the ESRF have revealed details of the microscopic atomic structure of water under extreme conditions. The results have now been published in the Proceedings of the National Academy of Sciences of the USA. Liquid water remains a mystery even after decades of dedicated scientific investigations and researchers still struggle to fully describe its unusual structure and dynamics. At high temperatures and high pressures, water is in the so called...

2013-03-12 22:45:12

New technique enables more precise design of tissue architecture Researchers at Columbia Engineering have developed a new "plug-and-play" method to assemble complex cell microenvironments that is a scalable, highly precise way to fabricate tissues with any spatial organization or interest–such as those found in the heart or skeleton or vasculature. The study reveals new ways to better mimic the enormous complexity of tissue development, regeneration, and disease, and is published in...