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Latest Nature Biotechnology Stories

2012-01-16 10:57:10

Blocking cell-to-cell communication may prevent liver damage and improve drug safety, Rutgers University and Massachusetts General Hospital (MGH) investigators have developed a novel strategy to protect the liver from drug-induced injury and improve associated drug safety. In a report receiving advance online publication in the journal Nature Biotechnology, the team reports that inhibiting a type of cell-to-cell communication can protect against damage caused by liver-toxic drugs such as...

2012-01-16 10:39:27

Blocking cell-to-cell communication may prevent liver damage and improve drug safety Massachusetts General Hospital (MGH) investigators have developed a novel strategy to protect the liver from drug-induced injury and improve associated drug safety. In their report receiving advance online publication in the journal Nature Biotechnology, the team reports that inhibition of a type of cell-to-cell communication can protect against the damage caused by liver-toxic drugs such as acetaminophen....

2011-12-12 17:02:35

The promise of stem cell research for drug discovery and cell-based therapies depends on the ability of scientists to acquire stem cell lines for their research. A survey of more than 200 human embryonic stem cell researchers in the United States found that nearly four in ten researchers have faced excessive delay in acquiring a human embryonic stem cell line and that more than one-quarter were unable to acquire a line they wanted to study. "The survey results provide empirical data to...

2011-11-28 17:27:39

An international study, published today in the prestigious journal Nature Biotechnology, reveals more about human pluripotent stem cells and their genetic stability and has important implications for the development of therapies using these cells. Scientists from the University of Melbourne, University of NSW and CSIRO contributed to this study, which examined how the genome of 138 stem cell lines of diverse ethnic backgrounds changed when the cells were grown in the laboratory....

2011-11-28 17:19:58

Researchers from A*STAR Singapore took lead roles in a study that identified a portion of the genome mutated during long-term culture of human embryonic stem cells (hESCs). The study was a worldwide collaboration, led by Drs Peter Andrews of the University of Sheffield (UK), Paul Robson of the Genome Institute of Singapore (GIS), Steve Oh of Singapore's Bioprocessing Technology Institute (BTI), and Barbara Knowles and others in the international stem cell community. The GIS, IMB and BTI are...

2011-11-07 13:01:52

First legume genome sequence to improve livelihoods of smallholder farmers in the dryland tropics Once referred to as an "orphan crop" mainly grown by poor farmers, pigeonpea is now set to join the world's league of major food crops with the completion of its genome sequence. The completed genome sequence of pigeonpea is featured as an advance online publication on 06 November 2011 on the website of the journal Nature Biotechnology, the first ranked journal in the area of biotechnology....

Commanding Yeast Genes With Computers
2011-11-07 09:43:05

Scientists in Switzerland have managed to form a “feedback loop” between a computer and a common yeast, precisely controlling the switching on and off of specific genes. This could herald the ability to control biological processes, such as creating biofuel from microbes, Jason Palmer of BBC News reports. “The neat thing about this is that there are many people who have tried to do things like this by, for example, coding in the cell itself a synthetic circuit, putting...

2011-10-31 10:22:31

In a technical tour de force, scientists at Fox Chase Cancer Center have cataloged and cross-indexed the actions of 178 candidate drugs capable of blocking the activity of one or more of 300 enzymes, including enzymes critical for cancer and other diseases. Additionally, a free library of the results has been made available online to the research community. This unique library represents an important new tool for accelerating the development of an entire class of targeted cancer drugs. The...

2011-10-17 15:09:14

The South China Center for Innovative Pharmaceuticals, Sun Yat-Sen University, and BGI, the world's largest genomic organization, announced that they were among the research organizations from China, US and UK comprising an international research group that completed the genome sequence and comparison of two non-human primate animal models - Chinese rhesus macaque and cynomolgus. The study is published today online in the journal Nature Biotechnology. This study marks an important...

2011-10-13 11:32:22

Scientists have improved upon their own previous world-best efforts to pluck out just the right stem cells to address the brain problem at the core of multiple sclerosis and a large number of rare, fatal children´s diseases. Details of how scientists isolated and directed stem cells from the human brain to become oligodendrocytes — the type of brain cell that makes myelin, a crucial fatty material that coats neurons and allows them to signal effectively — were published...