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Latest Nature Medicine Stories

2012-01-12 21:04:55

Newly identified genetic alterations in T-ALL provides new potential treatment strategies for devastating childhood leukemia A new study published in the journal Nature Medicine by NYU Cancer Institute researchers, shows how the cancer causing gene Notch, in combination with a mutated Polycomb Repressive Complex 2 (PRC2) protein complex, work together to cause T- cell acute lymphoblastic leukemia (T-ALL). T-ALL is an aggressive blood cancer, predominately diagnosed in children. It...

Experimental 'Couch Potato Pill' May Also Prevent Heat Stroke
2012-01-09 14:12:48

According to a new study in the journal Nature Medicine, an experimental treatment known as the 'couch potato pill' may also help to prevent heatstroke in people genetically predisposed to it. The pill first received its name due its ability to mimic the effects of exercise in inactive laboratory mice, eliciting much excitement in the medical community that it might eventually prove useful in activity-disinclined human patients as well. Yet new research shows that the drug, known to...

2011-12-26 07:23:28

A team of Weizmann Institute scientists has turned the tables on an autoimmune disease. In such diseases, including Crohn's and rheumatoid arthritis, the immune system mistakenly attacks the body's tissues. But the scientists managed to trick the immune systems of mice into targeting one of the body's players in autoimmune processes, an enzyme known as MMP9. The results of their research appear today in Nature Medicine. Prof. Irit Sagi of the Biological Regulation Department and her...

2011-12-19 11:43:13

Mutant huntingtin protein appears to block activity of Sirt1, suggesting potential treatment target Treatment that increases brain levels of an important regulatory enzyme may slow the loss of brain cells that characterizes Huntington's disease (HD) and other neurodegenerative disorders. In a report receiving advance online publication in Nature Medicine, a Massachusetts General Hospital (MGH)-based research team reports that increased expression of Sirt1, one of a family of enzymes called...

2011-12-12 12:49:52

Researchers at the Stanford University School of Medicine report that they have identified the molecular pathway through which physical force contributes to scarring in mice. "Our study exposes one of the fundamental mechanisms by which the mechanical environment can directly increase inflammation, which is strongly implicated in scarring," said Geoffrey Gurtner, MD, professor and associate chair of surgery. Mice genetically engineered to lack an enzyme that is activated by mechanical...

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2011-12-05 20:57:23

Nature Medicine publishes a pioneering study about a protein that regulates the expression of hundreds of genes that have a crucial role in the progression of pancreatic cancer, gliomas and possibly many other kinds of tumor A study by researchers Raúl Méndez, ICREA Research Professor at the Institute for Research in Biomedicine (IRB Barcelona) and Pilar Navarro at the IMIM (Institut de Recerca Hospital del Mar, Barcelona) describes a new reprogramming mechanism...

2011-12-05 13:01:24

Damage to podocytes -- a specialized type of epithelial cell in the kidney -- occurs in more than 90 percent of all chronic kidney disease. Now researchers at the Stanford University School of Medicine have uncovered an unexpected pathway that reveals for the first time how these cells may regenerate and renew themselves during normal kidney function. This finding is an important step toward one day therapeutically coaxing the cells to divide, which could be used to treat people with...

2011-11-28 23:17:19

Brigham and Women's Hospital (BWH) researchers have created a vaccine that is more potent than traditional vaccines available today. The glycoconjugate vaccine prototype is 100 times more effective than traditional glycoconjugate vaccines. Their work is published in the December 2011 issue of Nature Medicine.   A glycoconjugate vaccine is comprised of covalently bound carbohydrate and protein molecules, and is the standard design for many vaccines used to protect against common...

2011-11-21 09:37:13

Controlling a stem cell transplant recipient´s immune response may be major key to successful bone regeneration A new study in Nature Medicine describes how different types of immune system T-cells alternately discourage and encourage stem cells to regrow bone and tissue, bringing into sharp focus the importance of the transplant recipient's immune system in stem cell regeneration. The study, conducted at the Center for Craniofacial Molecular Biology at the Ostrow School of...

2011-11-18 03:49:24

For people who initially survive a heart attack, a significant cause of death in the next few days is cardiac rupture -- literally, bursting of the heart wall. A new study by University of Iowa researchers pinpoints a single protein as the key player in the biochemical cascade that leads to cardiac rupture. The findings, published Nov. 13 as an Advance Online Publication (AOP) of the journal Nature Medicine, suggest that blocking the action of this protein, known as CaM kinase, may help...


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Nature Medicine
2012-09-24 08:10:29

Nature Medicine is a peer-reviewed academic journal established in 1995 and published monthly by the Nature Publishing Group, a division of Macmillan Publishers Ltd. As with other Nature journals, this periodical has no external Editorial Board, with editorial decisions being made by an in-house team. Nature Medicine publishes research articles, reviews, news and commentary pieces. Topics include cancer, cardiovascular disease, gene therapy, immunology, vaccines, and neuroscience. Research...

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