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2009-09-16 10:34:33

Disease mechanism in HIV infection decoded / Heidelberg virologists publish in "Cell Host & Microbe" In order to be able to ward off disease pathogens, immune cells must be mobile and be able to establish contact with each other. The working group around Professor Dr. Oliver Fackler in the Virology Department of the Hygiene Institute of the Heidelberg University Hospital has discovered a mechanism in an animal model revealing how HIV, the AIDS pathogen, cripples immune cells: Cell...

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2009-07-27 09:30:00

Not satisfied with simply thwarting its host's defensive maneuvers, HIV actually twists one to its advantage, based on new findings from Kyei et al. in the July 27, 2009 issue of the Journal of Cell Biology (www.jcb.org). Vojo Deretic and colleagues suggest that autophagy"”a stress response process"”helps HIV to proliferate and that conversely, blocking autophagy lessens HIV production.Reduced HIV levels were accompanied by a blockade in the processing of Gag"”a key...

2009-07-13 13:30:56

One of the continuing mysteries of the HIV/AIDS epidemic is why women usually develop lower viral levels than men following acute HIV-1 infection but progress faster to AIDS than men with similar viral loads. Now a research team based at the Ragon Institute of Massachusetts General Hospital (MGH), MIT and Harvard has found that a receptor molecule involved in the first-line recognition of HIV-1 responds to the virus differently in women, leading to subsequent differences in chronic T cell...

2009-05-17 12:00:00

--Gene Transfer Technology May Lead to an HIV Vaccine-- PHILADELPHIA, May 17 /PRNewswire-USNewswire/ -- A research team may have broken the stubborn impasse that has frustrated the invention of an effective HIV vaccine, by using an approach that bypasses the usual path followed by vaccine developers. By using gene transfer technology that produces molecules that block infection, the scientists protected monkeys from infection by a virus closely related to HIV -- the simian immunodeficiency...

2009-05-15 08:43:00

ANN ARBOR, Mich., May 15 /PRNewswire-USNewswire/ -- New Enterprise Forum will host is third annual "Entrepreneurial Improv: The Battle of the Elevator Pitch," an offbeat, slightly outrageous event that highlights how successful entrepreneurs must think fast on their feet. The event takes place at 5:00 p.m. on Thursday, May 21 at the Holiday Inn North Campus, 3600 Plymouth Road in Ann Arbor, Michigan. During the program, NEF will put four entrepreneurs in front of a judging panel and give...

2009-04-13 07:58:15

Mutations that help HIV hide from the immune system undermine the virus's ability to replicate, show an international team of researchers in the April 13 issue of the Journal of Experimental Medicine. The study was published online on March 23. When HIV infects a cell, a complex of human immune proteins called HLA (short for human leukocyte antigen) alert killer T cells by displaying bits of the virus on the surface of the cell. The T cells recognize these HIV fragments and mobilize an...

2009-02-13 06:43:00

ANN ARBOR, Mich., Feb. 13 /PRNewswire-USNewswire/ -- New Enterprise Forum will celebrate its 23rd year as a resource for Michigan entrepreneurs in conjunction with its annual awards presentations. The event takes place at 5:00 p.m. on Thursday, February 19 at the Holiday Inn North Campus on 3600 Plymouth Road in Ann Arbor, Michigan. At the event, awards will be given to entrepreneurs in the following categories: Best Presentation, Best Technology, and Best Business Model. In addition, Ted...

2009-01-16 09:20:00

Scientists have identified a new way to inhibit a molecule that is critical for HIV pathogenesis. The research, published by Cell Press in the January 16th issue of the journal Molecular Cell, presents a target for development of antiretroviral therapeutics that are likely to complement existing therapies and provide additional protection from HIV and AIDS. Infection of human cells with HIV-1 requires multiple events that involve complex interactions between viral elements and cellular...

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2006-06-16 00:35:00

WASHINGTON -- Mutations in a single gene may have turned the AIDS virus from a fairly benign infection of monkeys and apes into a global pandemic that has killed more than 25 million people in 25 years, researchers said on Thursday. The virus in humans appears to have lost a genetic characteristic that protected the immune system in apes and monkeys, the researchers report in this week's issue of the journal Cell. "The observed difference in Nef function may provide -- for the first time -- a...

2005-08-26 19:27:10

Irvine, Calif., Aug. 26, 2005 -- A simple, harmless virus might hold the key to the more effective and efficient development of HIV and anti-viral drugs, UCI chemical biologists have found. In order to better identify compounds that can outmaneuver a virus' effort to mutate and multiply, Gregory Weiss and Allison Olszewski employed this virus, called a bacteriophage, to learn how a HIV protein could respond to a new class of anti-viral molecules they have discovered. By constantly mutating...


Word of the Day
cock-a-hoop
  • Exultant; jubilant; triumphant; on the high horse.
  • Tipsy; slightly intoxicated.
This word may come from the phrase 'to set cock on hoop,' or 'to drink festively.' Its origin otherwise is unclear. A theory, according to the Word Detective, is that it's a 'transliteration of the French phrase 'coq a huppe,' meaning a rooster displaying its crest ('huppe') in a pose of proud defiance.' Therefore, 'cock-a-hoop' would 'liken a drunken man to a boastful and aggressive rooster.'
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