Latest Neocardiogenesis Stories

When a young athlete dies unexpectedly on the basketball court or the football field, it's both shocking and tragic. Now Stanford University School of Medicine researchers have, for the first time, identified the molecular basis for a condition called hypertrophic cardiomyopathy that is the most common cause for this type of sudden cardiac death. To do so, the Stanford scientists created induced pluripotent stem cells, or iPS cells, from the skin cells of 10 members of a family with a...

The use of stem-cells -- building-block cells that are harvested from embryos or adults -- to treat heart disease could rely on faith as much as it does science, after billions of dollars in research has not produced the results that researchers have been looking for. Questions and concerns on the topic arose during the recent opening of the multi-million-dollar Scottish Center for Regenerative Medicine (SCRM) in Edinburgh, chaired by Sir Ian Wilmut, the renowned scientist whose Dolly the...

(Ivanhoe Newswire) -- New research reveals new developments to reprogram scar tissue, that is a result from myocardial infarction (MI), into heart muscle cells.  Scientists believe the new approach is a "game changer" with potential to revolutionise treatment of MI. "Our ultimate hope is that, during the acute period following MI, patients will be able to receive direct injections of factors that transform the existing fibroblast cells in the "scar" into new myocytes.  The resulting...

The latest research developments to reprogram scar tissue resulting from myocardial infarction (MI) into viable heart muscle cells, were presented at the Frontiers in CardioVascular Biology (FCVB) 2012 meeting, held 30 March to 1 April at the South Kensington Campus of Imperial College in London. In a keynote lecture Dr Deepak Srivastava outlined his approach that has been described as a "game changer" with the potential to revolutionize treatment of MI. For the first time at the FCVB...

Study has implications for reprogramming human cardiac myocytes to replace damaged heart muscleStem cell researchers at UCLA have uncovered for the first time why adult human cardiac myocytes have lost their ability to proliferate, perhaps explaining why the human heart has little regenerative capacity.The study, done in cell lines and mice, may lead to methods of reprogramming a patient's own cardiac myocytes within the heart itself to create new muscle to repair damage, said Dr. Robb...

US scientists have found that newborn mice can repair themselves after an injury, an important discovery that brings hopes that healing can occur with damaged hearts in people. Scientists removed large chunks of heart out of mice that were only a day old, only to find that their hearts were restored within three weeks. Fish and amphibians are known to have the power to re-grow parts of their hearts after major injuries, but the study, published in the journal Science, is the first time the...

ATLANTA, March 16 /PRNewswire/ -- CorMatrix Cardiovascular, Inc., a medical device company dedicated to developing and delivering unique extracellular matrix (ECM) biomaterial devices that harness the body's innate ability to repair damaged cardiovascular tissue, announced today that investigators from the Mercer University School of Medicine, Emory University and CorMatrix Cardiovascular, Inc. demonstrated that an injectable emulsion of the company's ECM Technology enhances angiogenesis...

Researchers appear to have a new way to fix a broken heart. They have devised a method to coax heart muscle cells into reentering the cell cycle, allowing the differentiated adult cells to divide and regenerate healthy heart tissue after a heart attack, according to studies in mice and rats reported in the July 24th issue of the journal Cell, a Cell Press publication. The key ingredient is a growth factor known as neuregulin1 (NRG1 for short), and the researchers suggest that the factor might...

U.S. researchers, in a study in mice, found bone marrow stem cells improve cardiac function. Study author Dr. Yerem Yeghiazarians of the University of California, San Francisco, and colleagues administered three different groups of mice with bone marrow cells, bone marrow cell extract, or saline for the control group. The injections were administered three days after a heart attack. At day 28, both the bone marrow cell group and the extract group had significantly smaller heart damage...

U.S. researchers say they are seeking people for a trial to test the safety of using patients' own stem cells to repair their damaged hearts. Half of the participants will be ischemic heart disease patients with blood flow problems due to arterial disease and the other half will have the non-ischemic form caused by an enlarged heart muscle. All will have limited or no other treatment options. The one-year, randomized and controlled study -- Phase II Cardiac Repair Cell Treatment of Patients...