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Last updated on April 16, 2014 at 11:02 EDT

Latest Neprilysin Stories

2011-06-15 22:18:50

The team traced the development of a unique feature in a species of fruit fly that began with low-level gene activity and became a distinct feature in a mere four mutations as an existing gene took on a new function, according to a report in PNAS Small genetic mutations that add up over time could create an evolutionary express lane that leads to the rapid development of new traits, researchers from the University of Pittsburgh and the University of Wisconsin at Madison have found. The team...

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2010-12-10 08:20:54

Simple small molecules could untangle complex disease New molecular tools developed at the University of Michigan show promise for "cleansing" the brain of amyloid plaques, implicated in Alzheimer's disease. A hallmark of Alzheimer's disease"”a neurodegenerative disease with no cure"”is the aggregation of protein-like bits known as amyloid-beta peptides into clumps in the brain called plaques. These plaques and their intermediate messes can cause cell death, leading to the...

2010-06-04 14:13:39

Reducing a protein called beta-amyloid in young mice with a condition resembling Down syndrome improves their ability to learn, researchers at UT Southwestern Medical Center have found. "This preliminary study in the animal model raises the intriguing possibility that drugs that lower beta-amyloid levels might offer some benefit to children with Down syndrome," said Dr. Craig Powell, assistant professor of neurology at UT Southwestern and co-lead author of the study, which is available in...

2009-11-10 08:54:18

Saint Louis U. researchers find low doses of protein linked to Alzheimer's disease enhances memory in healthy While too much amyloid beta protein in the brain is linked to the development of Alzheimer's disease, not enough of the protein in healthy brains can cause learning problems and forgetfulness, Saint Louis University scientists have found. The finding could lead to better medications to treat Alzheimer's disease, said John Morley, M.D., director of the division of geriatrics at Saint...

2008-07-02 12:01:11

U.S. scientists say the protein neprilysin can reduce plaque formation and neuron death associated with Alzheimer's disease, but at the expense of lifespan. Thomas Jefferson University researchers said the buildup of amyloid-beta protein plaques within the brain is a hallmark of Alzheimer's. Normally, enzymes remove the plaques, and deficiencies in those enzymes are one potential disease cause. The scientists said neprilysin, or NEP, a major amyloid degrader, decreases naturally with age...

2008-06-25 12:03:12

U.S. medical scientists say they have identified a gene that puts people at risk for developing Alzheimer's disease. Philippe Marambaud of the Feinstein Institute for Medical Research and Fabien Campagne of the Weill Medical College at Cornell University said the calcium channel modulator gene holds promise as a potentially new way to treat or even prevent Alzheimer's disease. They said they found the risk gene called CALHM1 strongly expressed in the hippocampus -- a brain region...