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2013-11-19 23:03:33

Reportbuyer.com just published a new market research report: Orphan Drugs in Oncology Drug Pipeline Update 2013. London (PRWEB) November 19, 2013 This is a worldwide report on cancer drugs which have now or in the past received orphan drug status. This product will give you unique access not only to those cancer indications in which drugs are being granted orphan drug status, but also detailed insights in to their mechanism of action and developmental strategy. The orphan drug designation...

2012-04-03 09:09:25

Johns Hopkins investigators are testing a way to use drugs that target a cholesterol pathway to enhance the cancer-killing potential of standard chemotherapy drugs. Their tests, in mouse models of pancreatic cancer, may yield new and more effective combinations of current and possibly new anti-cancer drugs. Besides their deadly consequences, pancreatic cancer and heart disease share a connection with genetic pathways that control cholesterol and a cell signaling system known as the...

2011-10-27 15:37:17

FINDINGS: Whitehead Institute scientists have determined that master transcription factors determine the genes regulated by key signaling pathways. In this way, signaling pathways are targeted to genes that are most relevant to each cell type and tailor gene expression to control cell state, growth, differentiation, and death. RELEVANCE: When signaling pathways operate properly, a cell receives instructions from its neighbors and the environment that tweak gene expression and control the...

Image 1 - Biochemical Cell Signals Quantified For The First Time
2011-09-18 06:16:17

  Just as cell phones and computers transmit data through electronic networks, the cells of your body send and receive chemical messages through molecular pathways. The term “cell signaling” was coined more than 30 years ago to describe this process. Now, for the first time, scientists have quantified the data capacity of a biochemical signaling pathway and found a surprise — it´s way lower than even an old-fashioned, dial-up modem. “This key...

2011-08-01 16:30:33

Blocking a growth factor receptor cripples cancer growth in a form of T cell leukemia, according to a study published online on August 1 in the Journal of Experimental Medicine (www.jem.org). Approximately half of the cases of T cell acute lymphoblastic leukemia (T-ALL) carry genetic mutations in a cellular signaling pathway called Notch, which result in aberrant activation of the cell. A study by Andrew Weng and colleagues at the British Columbia Cancer Agency now shows that activation of...

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2010-03-09 11:45:07

A Princeton University-led research team has discovered that protein competition over an important enzyme provides a mechanism to integrate different signals that direct early embryonic development. The work suggests that these signals are combined long before they interact with the organism's DNA, as was previously believed, and also may inform new therapeutic strategies to fight cancer. The fought-over enzyme, known as the mitogen-activated protein kinase (MAPK), is found in all complex...

2009-11-25 14:59:29

M. D. Anderson-led team connects the dots among three distinct components of cancer development, potentially pointing the way to new therapeutic strategies Two signaling pathways essential to normal human development - the Wnt/Wingless (Wnt) and epidermal growth factor receptor (EGFR) pathways - interact in ways that can promote tumor cell invasion and metastasis, researchers from The University of Texas M. D. Anderson Cancer Center report in the Nov. 25 issue of Molecular Cell. This newly...


Word of the Day
attercop
  • A spider.
  • Figuratively, a peevish, testy, ill-natured person.
'Attercop' comes from the Old English 'atorcoppe,' where 'atter' means 'poison, venom' and‎ 'cop' means 'spider.' 'Coppa' is a derivative of 'cop,' top, summit, round head, or 'copp,' cup, vessel, which refers to 'the supposed venomous properties of spiders,' says the OED. 'Copp' is still found in the word 'cobweb.'
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