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Latest Neuroblastoma Stories

2012-05-22 02:44:41

An inexpensive "orphan drug" used to treat sleep disorders appears to be a potent inhibitor of cancer cells, according to a new study led by scientists at Fred Hutchinson Cancer Research Center. Their novel approach, using groundbreaking technology that allows rapid analysis of the genome, has broad implications for the development of safer, more-effective cancer therapies. The findings are published in the May 21 issue of the Proceedings of the National Academy of Sciences. A research...

2012-05-17 12:58:20

Important advances in treatment for aggressive cancers and supportive care The American Society of Clinical Oncology (ASCO) today highlighted five studies in a press briefing from among more than 4,500 abstracts publicly posted online at abstract.asco.org in advance of ASCO's 47th Annual Meeting. Plenary, late-breaking and other major studies will be released in on-site press conferences at the Annual Meeting to be held June 1-5, 2012, at McCormick Place in Chicago, Ill. The meeting,...

2012-05-17 12:14:34

Children's Hospital of Philadelphia researcher leads trial of ALK inhibitor in neuroblastoma, lymphoma A pill designed to zero in on abnormal genes that drive specific cancers has produced encouraging early results in children with an uncommon but aggressive type of lymphoma, as well as in children with a rare form of neuroblastoma. A phase 1 clinical trial of the drug crizotinib achieved remissions, with minimal side effects, for 10 of the children participating in a clinical study...

2012-05-16 14:22:19

PHILADELPHIA, May 16, 2012 /PRNewswire/ -- A pill designed to zero in on abnormal genes that drive specific cancers has produced encouraging early results in children with an uncommon but aggressive type of lymphoma, as well as in children with a rare form of neuroblastoma. To view the multimedia assets associated with this release, please visit: http://www.multivu.com/mnr/50776-childrens-hospital-philadelphia-lymphoma-neuroblastoma-oncology-gene-trial (Photo:...

2012-05-09 21:35:10

Study is first to show feasibility and efficacy of a new use for autologous stem cell transplant For the first time, scientists at Fred Hutchinson Cancer Research Center have transplanted brain cancer patients' own gene-modified blood stem cells in order to protect their bone marrow against the toxic side effects of chemotherapy. Initial results of the ongoing, small clinical trial of three patients with glioblastoma showed that two patients survived longer than predicted if they had not...

2012-05-09 19:41:46

Ongoing research by a Baylor College of Medicine pediatric oncologist to understand how special cells called natural killer T (NKT) cells can be used to suppress neuroblastoma tumor growth has led to the discovery that the protein IL-15 is key to protecting the NKT cells' anti-tumor effectiveness in a hostile environment. The study, led by Dr. Leonid Metelitsa, associate professor of pediatrics — hematology/oncology at BCM and Texas Children's Cancer Center, appears in the current...

2012-04-30 10:27:35

St. Jude Children's Research Hospital closes survival gap for virtually all African-American and white children with cancer in a study that suggests equal access to care translates into an equal chance of a cure MEMPHIS, Tenn., April 30, 2012 /PRNewswire-USNewswire/ -- A new analysis from St. Jude Children's Research Hospital adds to evidence that equal access to comprehensive treatment and supportive care typically translates into equally good outcomes for most young African-American...

2012-04-13 05:28:27

(Ivanhoe Newswire) -- Around 80 percent of children with acute lymphoblastic leukemia (ALL) are now cured. With advancing treatment the cure rate may reach close to 90! Sounds promising right? According to a recent study, this figure is deceptive for children with unfavorable features defined by response to treatment or disease biology. In fact, some groups of children face a 50 percent cure rate. For example, a child with induction failure, where complete remission is not achieved after 4...

2012-03-14 11:49:00

St. Jude Children's Research Hospital — Washington University Pediatric Cancer Genome Project and Memorial Sloan-Kettering Cancer Center discover first gene alteration associated with patient age and neuroblastoma outcome Researchers have identified the first gene mutation associated with a chronic and often fatal form of neuroblastoma that typically strikes adolescents and young adults. The finding provides the first clue about the genetic basis of the long-recognized but poorly...

2012-03-13 22:34:15

Certain mutations of the gene ATRX were associated with age at diagnosis in children and young adults with advanced-stage neuroblastoma, a cancer that grows in parts of the nervous system, according to a study in the March 14 issue of JAMA. Neuroblastoma is the most common extracranial (outside the cranium) solid tumor of childhood and accounts for 15 percent of all cancer-related deaths in children. "Half of the patients (50 percent) with neuroblastoma present with metastatic disease;...