Latest Neurodegeneration Stories

Researchers at Georgetown University Medical Center have used tiny doses of a leukemia drug to halt accumulation of toxic proteins linked to Parkinson's disease in the brains of mice. This finding provides the basis to plan a clinical trial in humans to study the effects. They say their study, published online May 10 in Human Molecular Genetics, offers a unique and exciting strategy to treat neurodegenerative diseases that feature abnormal buildup of proteins in Parkinson's disease,...

Research opens door to new drug therapies for Parkinson’s disease McGill University researchers have unlocked a new door to developing drugs to slow the progression of Parkinson’s disease. Collaborating teams led by Dr. Edward A. Fon at the Montreal Neurological Institute and Hospital -The Neuro, and  Dr. Kalle Gehring  in the Department of Biochemistry at the Faculty of Medicine, have discovered the three-dimensional structure of the protein Parkin. Mutations in Parkin cause a rare...

--After Successful Pre-IND Meeting, Company On Track to Advance Lead Compound NPT002 into Clinical Trials for Alzheimer's Disease in 2014-- CAMBRIDGE, Mass., May 6, 2013 /PRNewswire/ -- NeuroPhage Pharmaceuticals, Inc., a company developing breakthrough therapies for neurodegenerative diseases, today announced that it raised $6.4 million in a private equity financing round. Merieux Developpement led the financing with participation from all current Neurophage investors, including...

Research published in the May 2013 journal GENETICS may shed light on the root cause of some neurodegenerative diseases Scientists have identified a gene that keeps our nerve fibers from clogging up. Researchers in Ken Miller's laboratory at the Oklahoma Medical Research Foundation (OMRF) found that the unc-16 gene of the roundworm Caenorhabditis elegans encodes a gatekeeper that restricts flow of cellular organelles from the cell body to the axon, a long, narrow extension that neurons use...

A protein known to be a key player in the development of Parkinson's disease is able to enter and harm cells in the same way that viruses do, according to a Loyola University Chicago Stritch School of Medicine study. The protein is called alpha-synuclein. The study shows how, once inside a neuron, alpha synuclein breaks out of lysosomes, the digestive compartments of the cell. This is similar to how a cold virus enters a cell during infection. The finding eventually could lead to the...

redOrbit Staff & Wire Reports - Your Universe Online New research published Thursday in the journal Neuron sheds new light on the molecular causes of Alzheimer’s disease, while also revealing a potential new therapy which could help prevent cognitive decline and brain damage during the early stages of the neurodegenerative disorder. The study focuses on a variant of a gene known as CD33, which typically contributes to Alzheimer’s disease by inhibiting the ability of a body’s...

Researchers have recently discovered that an expansion of DNA in patients with the common neurodegenerative disorder Fragile X-associated Tremor syndrome causes the production of an abnormal protein that is toxic to neurons. The findings, which are reported online April 18 in the Cell Press journal Neuron, suggest an unexpected process by which DNA expansions might lead to neurodegenerative diseases—including Huntington's disease and ALS. This discovery reveals a common feature among these...

Rockefeller Plaza Exhibit Highlights Hope for the Growing Health Concern NEW YORK, April 2, 2013 /PRNewswire/ -- As the leader for research in ALS, the devastating brain disorder also known as Lou Gehrig's disease, Project A.L.S. has been selected by EHE International to raise awareness about ALS and related brain diseases in a 103-square foot window display in Rockefeller Plaza. The interactive Project A.L.S. exhibit debuts today in the major international thoroughfare, and will be...

The most common genetic cause of both ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) was recently identified as an alteration in the gene C9orf72. But how the mutation causes neurodegenerative disease appeared mysterious. Researchers at Emory University School of Medicine have demonstrated that this ALS/FTD mutation may be harmful because it creates an "RNA sponge," soaking up an important regulatory protein that binds RNA. The results were published online Monday...

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