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Latest Neurodegenerative disease Stories

2012-06-28 22:17:46

Corrected cells are generating normal neurons in mouse model of the disease Researchers at the Buck Institute for Research on Aging have corrected the genetic mutation responsible for Huntington's Disease (HD) using a human induced pluripotent stem cell (iPSC) that came from a patient suffering from the incurable, inherited neurodegenerative disorder. Scientists took the diseased iPSCs, made the genetic correction, generated neural stem cells and then transplanted the mutation-free cells...

2012-06-28 12:58:38

In a genome-wide association (GWA) study, researchers from Boston University Schools of Medicine (BUSM) and Public Health (BUSPH) have identified several genes which influence degeneration of the hippocampus, the part of the brain most associated with Alzheimer disease (AD). The study, which currently appears online as a Rapid Communication in the Annals of Neurology, demonstrates the efficacy of endophenotypes for broadening the understanding of the genetic basis of and pathways leading to...

2012-06-27 07:05:57

Long-term aim is to develop new treatments to block the spread of damaged proteins in the brain Grand Rapids, Mich. (June 27, 2012) — Van Andel Institute announces that researchers at Lund University in Sweden have published a study detailing how Parkinson's disease spreads through the brain. Experiments in rat models uncover a process previously used to explain mad cow disease, in which misfolded proteins travel from sick to healthy cells. This model has never before been identified...

2012-06-21 06:19:46

(Ivanhoe Newswire) — More than 15,000 Americans have Huntington´s disease, a fatal condition marked by uncontrolled movements and cognitive and psychiatric problems. Currently, there are no available treatments to alter the effects of Huntington´s disease, but a new study brings researchers one step closer to finding one. A new gene-silencing strategy can reverse core symptoms associated with Huntington's disease, according to a preclinical study. The short-term therapy...

2012-06-21 02:21:23

Single treatment produces long-term improvement in animal models With a single drug treatment, researchers at the Ludwig Institute for Cancer Research at the University of California, San Diego School of Medicine can silence the mutated gene responsible for Huntington's disease, slowing and partially reversing progression of the fatal neurodegenerative disorder in animal models. Researchers suggest the drug therapy, tested in mouse and non-human primate models, could produce sustained...

2012-06-21 02:19:04

A new gene-silencing strategy can reverse core symptoms associated with Huntington's disease, according to a preclinical study published by Cell Press in the June 21st issue of the journal Neuron. The short-term therapy produced sustained benefits in both mouse and primate animal models of this neurodegenerative disorder, which currently lacks an effective treatment. "Our approach is feasible for development now into a therapy for Huntington's disease in man," says senior study author Don...

2012-06-19 11:10:05

A new study shows that the compound Coenzyme Q10 (CoQ) reduces oxidative damage, a key finding that hints at its potential to slow the progression of Huntington disease. The discovery, which appears in the inaugural issue of the Journal of Huntington's Disease, also points to a new biomarker that could be used to screen experimental treatments for this and other neurological disorders. "This study supports the hypothesis that CoQ exerts antioxidant effects in patients with Huntington's...

2012-06-08 10:38:34

Using a new and powerful approach to understand the origins of neurodegenerative disorders such as Alzheimer's disease, researchers at Mayo Clinic in Florida are building the case that these diseases are primarily caused by genes that are too active or not active enough, rather than by harmful gene mutations. In the June 7 online issue of PLoS Genetics, they report that several hundred genes within almost 800 brain samples of patients with Alzheimer's disease or other disorders had altered...

Scientists Reprogram Skin Cells To Brain Cells
2012-06-08 06:19:29

Connie K. Ho for redOrbit.com For the first time, scientists at Gladstone Institute have changed skin cells, imbued with a single genetic factor, into cells that can become a group of interconnecting, functional brain cells. The findings show that there may be options in combating neurological conditions. This transformation of cells would pave the way for better methods in testing drugs for neurodegenerative conditions like Alzheimer´s disease. The research follows increased...

2012-06-08 05:21:12

(Ivanhoe Newswire) — Stem cells have the ability to create incredible breakthroughs within the medical world. Stem cells have the remarkable potential to make themselves into almost any cell within the human body during the early stages of life. Scientists at the Gladstone Institutes have for the first time transformed skin cells into a functional network of brain cells. The research offers new hope in the fight against many neurological conditions because scientists expect that such...


Word of the Day
vermicular
  • Like a worm in form or movement; vermiform; tortuous or sinuous; also, writhing or wriggling.
  • Like the track or trace of a worm; appearing as if worm-eaten; vermiculate.
  • Marked with fine, close-set, wavy or tortuous lines of color; vermiculated.
  • A form of rusticated masonry which is so wrought as to appear thickly indented with worm-tracks.
This word ultimately comes from the Latin 'vermis,' worm.
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