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Latest Neurodegenerative disease Stories

2011-12-23 06:48:49

(Ivanhoe Newswire) — Treatment that increases brain levels of a crucial regulatory enzyme may slow the loss of brain cells that characterize Huntington´s disease (HD) and other neurodegenerative disorders, according to this study. Increased expression of Sirt1, one of a family of enzymes called sirtuins, in the brain of a mouse model of HD protected against neurodegeneration. They also identified a potential mechanism for this protective effect. "Diseases such as Huntington's,...

2011-12-12 22:24:40

Amyotrophic lateral sclerosis (ALS; also known as Lou Gehrig's disease) is an incurable adult neurodegenerative disorder that progresses to paralysis and death. Genetic mutations are the cause of disease in 5% of patients with ALS. Of immense interest, Hongxia Zhou, Xu-Gang Xia, and colleagues, at Thomas Jefferson University, Philadelphia, now show that progressive neuron degeneration can be halted in a rat model of familial ALS linked to mutations in the gene that carries the instructions...

2011-11-28 06:51:33

(Ivanhoe Newswire) — According to a recent study, two proteins conspire to promote a lethal neurological disease. Amyotrophic lateral sclerosis, ALS, also known as Lou Gehrig´s disease, is a neurodegenerative disorder that results in progressing loss of motor function and ultimately death. More than 90 percent of ALS cases have no known genetic cause or family history. However, in some patients, spinal cord cells contain unusual accumulations of a protein called TDP-43....

2011-11-14 23:12:47

Two proteins conspire to promote a lethal neurological disease, according to a study published online this week in the Journal of Experimental Medicine (www.jem.org). Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a devastating neurodegenerative disorder that results in progressive loss of motor function and ultimately death. More than 90% of ALS cases have no known genetic cause or family history. However, in some patients, spinal cord cells contain unusual...

2011-11-07 19:59:07

Hirano bodies are almost indescribably tiny objects found in nerve cells of people suffering from conditions such as Alzheimer's, mad cow and Lou Gehrig's diseases. Yet for decades, researchers weren't sure if these structures helped cause the conditions or appeared after onset of the disease and had some other role. Now, in research at the University of Georgia, a cellular biologist and his colleagues have found that Hirano bodies may play a protective role in the progression of...

2011-10-31 10:16:28

Breakthrough discovery paves way for potential treatments Scientists at the Gladstone Institutes have discovered how a form of the protein linked to Huntington's disease influences the timing and severity of its symptoms, offering new avenues for treating not only this disease, but also a variety of similar conditions. In a paper being published today in Nature Chemical Biology, the laboratory of Gladstone Senior Investigator Steven Finkbeiner, MD, PhD, singles out one form of a...

Researchers Study Aging's Effect On The Brain
2011-10-11 03:50:45

Research by biologists at the University of York and Hull York Medical School has revealed important new information about the way the brain is affected by age. Working with scientists at the Peninsula College of Medicine and Dentistry in Plymouth, they have studied responses to stress in synapses -- neuronal connections. The researchers discovered that under stressful conditions, such as neuro-degeneration, resulting high energy forms of damaging oxygen cause synapses to grow...


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