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Latest Neurodegenerative disease Stories

2011-09-26 15:10:06

New research in the FASEB Journal suggests that prenatal exercise improves brain plasticity, decreases toxic protein deposits, inflammation and oxidative stress, which wards off Alzheimer's and other diseases If you are pregnant, here's another reason to work out: you will reduce the chances of your new baby developing neurodegenerative diseases, such as Alzheimer's, later in life. A new research report published online in The FASEB Journal (http://www.fasebj.org) shows that mice bred to...

Genetic Mutation Linked To Lou Gehrig's Disease And Dementia
2011-09-22 05:00:53

   Scientists have identified a new human genetic mutation that is responsible for the most common cause of Lou Gehrig's disease and dementia. The researchers performed a genetic analysis and determined that a genetic mutation in the gene C9ORF72 was found in almost 12 percent of all dementia patients in the study and over 22 percent in all amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease patients. "This finding has the potential to lead to significant insights...

2011-09-20 11:58:25

Stem cell technology from Tel Aviv University research begins clinical trial for Lou Gehrig's disease The ability to produce neuroprotectors, proteins that protect the human brain against neurodegenerative disorders such as Parkinson's and ALS, is the holy grail of brain research. A technology developed at Tel Aviv University does just that, and it's now out of the lab and in hospitals to begin clinical trials with patients suffering from amyotrophic lateral sclerosis (ALS), also known as...

2011-09-19 22:39:17

Aging is a major risk factor for the progression of neurodegenerative diseases, including Huntington disease (HD). Morris White and colleagues, at Harvard Medical School, Boston, have now determined that modulating levels of the signaling protein Irs2 changes disease progression in a mouse model of HD. Specifically, increasing Irs2 levels in the brain increased nerve cell damage and reduced lifespan. Conversely, decreasing Irs2 levels reduced nerve cell damage, attenuated symptoms of disease,...

2011-09-15 12:53:56

Collaborative study using Allen Spinal Cord Atlas finds previously overlooked cell type with implications for treating spinal cord injury and disease The Allen Institute for Brain Science announced today the discovery of a new class of cells in the spinal cord that act like neural stem cells, offering a fresh avenue in the search for therapies to treat spinal cord injury and disease. The published collaborative study, authored by scientists from the University of British Columbia, the...

2011-09-12 11:18:25

Earlier this year, an international consortium of researchers showed that a master gene called transcription factor EB or TFEB controls both the mechanism by which debris is gathered up in cell and that which destroys it. In a report in the current issue of the journal Developmental Cell, Dr. Andrea Ballabio, scientific director at the Telethon Institute of Genetics and Medicine in Naples Italy, and a professor of molecular and human genetics at Baylor College of Medicine and the Jan and...

2011-09-06 09:00:00

SHENZHEN, China and SAN DIEGO, Calif., Sept. 6, 2011 /PRNewswire-Asia/ -- The Journal of Translational Medicine reports on a new study in which 30 patients with Hereditary Ataxia showed statistically significant improvements in functionality and quality of life after being treated with a combination of cord blood-derived stem cell treatments and physical therapy. The study was conducted at the Nanshan Affiliated Hospital of Guangdong Medical College in China, and included the...

2011-09-06 07:00:00

CAMBRIDGE, Mass. and NEW YORK, Sept. 6, 2011 /PRNewswire/ -- Galenea Corp. and CHDI Foundation, Inc. have announced a collaboration to identify synaptic dysfunction linked to Huntington's disease (HD) utilizing Galenea's proprietary synaptic transmission drug discovery platform. Mounting evidence indicates that mutant huntingtin protein, the molecular defect in HD, disrupts normal synaptic function, contributing to the behavioral, cognitive, and motor symptoms of this devastating...

2011-08-24 21:53:33

Evidence found for a neuronal switch to prevent neurodegenerative diseases Scientists at Northwestern University report a surprising discovery that offers a possible new route for the treatment of neurodegenerative diseases. In a study of the transparent roundworm C. elegans, they found that a genetic switch in master neurons inhibits the proper functioning of protective cell stress responses, leading to the accumulation of misfolded and damaged proteins. Neurodegenerative diseases,...

2011-08-18 00:00:43

NextGen Group plc (AIM:NGG) is pleased to announce that its US-subsidiary NextGen Sciences Inc, has been contracted by investigators at the NIMH-funded Chronic HIV Infection and Aging in NeuroAIDS (CHAIN) Center at the University of Nebraska Medical Center (UNMC) to utilize their innovative and sensitive csfdiscovery43 assay to examine biomarkers in CSF (cerebrospinal fluid) associated with neuroAIDS. The csfdiscovery43 assay simultaneously measures 43 human CSF proteins that are thought to...