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Last updated on April 16, 2014 at 7:25 EDT

Latest Neurofibrillary tangle Stories

2012-01-04 07:45:00

Analysis of Available Biomarkers Will Guide FDA and Industry in Design of Clinical Trials to Speed Search for Disease-Modifying Treatments WASHINGTON, Jan. 4, 2012 /PRNewswire-USNewswire/ -- A group of thought leaders in Alzheimer's disease says the science is solid and the time has come for more widespread use of biomarkers in Alzheimer disease (AD) clinical trials, to speed the identification of effective disease-modifying treatments for this incurable disorder. Recommendations by the...

2011-11-02 09:06:07

Neurofibrillary tangles — odd, twisted clumps of protein found within nerve cells — are a pathological hallmark of Alzheimer's disease. The tangles, which were first identified in the early 1900s by German psychiatrist and neuropathologist Aloysius Alzheimer, are formed when changes in a protein called tau cause it to aggregate in an insoluble mass in the cytoplasm of cells. Normally, the tau protein is involved in the formation of microtubules, hollow filaments that provide cells...

2011-10-17 14:04:56

Antiviral drugs used to target the herpes virus could be effective at slowing the progression of Alzheimer's disease (AD), a new study shows. The University of Manchester scientists have previously shown that the herpes simplex virus type 1 (HSV1) is a risk factor for Alzheimer's when it is present in the brains of people who have a specific genetic risk to the disease. AD is an incurable neurodegenerative condition affecting about 18 million people worldwide. The causes of the disease...

2011-09-07 19:35:01

Alzheimer's disease (AD) is a devastating neurodegenerative disorder that causes progressive cognitive impairment and memory loss. Now, a new study published by Cell Press in the September 8 issue of the journal Neuron identifies a previously unrecognized link between neuroinflammation and the classical pathological brain changes that are the hallmark of the disease. In addition, the research identifies a new potential therapeutic target for AD. AD is characterized by abnormal accumulation...

2011-07-25 08:45:00

HOBOKEN, NJ, July 25, 2011 /PRNewswire/ - Anavex Life Sciences Corp. ("Anavex") (OTCBB: AVXL) is pleased to provide a summary of the first of two poster presentations at the Alzheimer's Association International Conference (AAIC) held in Paris, entitled "The novel aminotetrahydrofuran derivative ANAVEX 2-73 attenuated GSK-3beta and Tau hyperphosphorylation in a nontransgenic Alzheimer's disease model in mice." Researchers injected oligomeric amyloid 25-35 fragments into the brain...

2011-07-07 06:52:34

(Ivanhoe Newswire) "“ The little-studied amyloid peptide may be promoting Alzheimer's disease (AD), according to this study. Their findings show that the peptide is more abundant, more neurotoxic, and exhibits a higher propensity to aggregate than other agents studied earlier. An irreversible, progressive brain disease affecting millions worldwide, Alzheimer's disease is devastating for its victims, robbing them of their memory and cognitive skills and ultimately of their lives. Even...

2011-07-03 12:35:02

Highly aggregative and neurotoxic amyloid peptide Abeta43 points the way to new approaches for AD diagnosis and treatmentTokyo, July 4, 2011 - (ACN Newswire) - Researchers at the RIKEN Brain Science Institute (BSI) and their collaborators have shed light on the function of a little-studied amyloid peptide in promoting Alzheimer's disease (AD). Their surprising findings reveal that the peptide is more abundant, more neurotoxic, and exhibits a higher propensity to aggregate than amyloidogenic...

2011-06-29 18:13:55

Overexpression of gene is linked with Alzheimer's disease and down syndrome Chronic stress has long been linked with neurodegeneration. Scientists at USC now think they may know why. The study, which has tremendous implications for understanding and treating Alzheimer's disease, was published in the June issue of The FASEB Journal (the Journal of the Federation of American Societies for Experimental Biology). Corresponding author Kelvin J. A. Davies, the James E. Birren Chair at the USC Davis...

2011-06-15 06:20:00

(Ivanhoe Newswire) -- A unique brain scanner is used to allow the assessment of amyloid plaques and neurofibrillary tangles- the hallmarks of Alzheimer's disease- in adults with Down syndrome. This finding may offer a new clinical tool to help diagnose dementia in adults with Down syndrome. Adults with this disorder develop Alzheimer's-like plaque and tangle deposits early, often before the age of 40. Previously, the only way to physically detect these abnormal proteins in this population was...

2011-06-14 01:33:52

In one of the first studies of its kind, UCLA researchers used a unique brain scan to assess the levels of amyloid plaques and neurofibrillary tangles "” the hallmarks of Alzheimer's disease "” in adults with Down syndrome. Published in the June edition of the Archives of Neurology, the finding may offer an additional clinical tool to help diagnose dementia in adults with Down syndrome, a genetic disorder caused by the presence of a complete or partial extra copy of chromosome...