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Latest neurofibromatosis Stories

2008-08-30 09:00:21

By Tischler, Arthur S * Context.-Advances in genetics and gene expression profiling have led to new ways of thinking about the pathobiology of pheochromocytoma and extra-adrenal paraganglioma. These developments are concurrent with the publication and dissemination of the 2004 World Health Organization bluebook on pathology and genetics of endocrine tumors. Objective.-To summarize new information required by pathologists for effective participation in patient management and research. Data...

2008-08-12 12:00:34

U.S. medical scientists say they have discovered a mutation that causes a childhood tumor syndrome also impairs growth hormone secretion. Washington University School of Medicine researchers said their discovery provides insights into a medical mystery: why patients with neurofibromatosis type 1 are frequently shorter than their peers. The researchers said the finding has led scientists to consider modifying their search for treatments for the inherited disorder, which is caused by a...

2008-07-06 18:00:07

By Faye Flam, The Philadelphia Inquirer Jul. 6--By completely reversing four types of mental impairment in mice, scientists are overturning the long-entrenched notion that our mental capacity is hardwired and immutable. So striking were the animal results that scientists are beginning drug trials on people with genetic disorders associated with mental retardation and autism. Several of the drugs are approved for other uses, which should speed up the testing process. Until recently,...

2008-03-26 03:00:08

By Rodriguez, Fausto J Perry, Arie; Gutmann, David H; O'Neill, Brian Patrick; Leonard, Jeffrey; Bryant, Sandra; Giannini, Caterina Abstract There are few pathologic studies of gliomas in patients with neurofibromatosis type 1. We analyzed clinical and pathologic features of gliomas from 100 neurofibromatosis type 1 patients (57 men; 43 women). The median age at tumor diagnosis was 13 years (range, 4 months to 68 years). Most tumors were typical pilocytic astrocytoma (PA) (49%) or diffusely...

2005-11-07 13:44:50

In a surprise twist that recalls the film classic "Flowers for Algernon," but adds a happy ending, UCLA scientists used statins, a popular class of cholesterol drugs, to reverse the attention deficits linked to the leading genetic cause of learning disabilities. The Nov. 8 issue of Current Biology reports the findings, which were studied in mice bred to develop the disease, called neurofibromatosis 1 (NF1). The results proved so hopeful, that the Food and Drug Administration approved the use...

2005-11-07 13:40:09

This week, researchers report evidence that a statin drug already shown to be safe for use in humans has proven effective at correcting cell-cell communication and curing learning disfunction in a mouse model of Neurofibromatosis type I, a human genetic disorder that causes learning disabilities in millions of people worldwide. Learning disabilities affect 5% of the world's population, have a profound impact on countless lives, and cost billions of dollars, but there is little or nothing...

2005-10-31 19:55:00

Oct. 31, 2005 "” Researchers studying a mouse model of neurofibromatosis 1 (NF1), a genetic condition that causes childhood brain tumors, have found their second new drug target in a year, a protein called methionine aminopeptidase-2 (MetAP2). An established drug, fumagillin, is already known to suppress the activity of MetAP2. Researchers at Washington University School of Medicine in St. Louis showed that fumagillin significantly slowed the rapid proliferation of cultured mouse brain...


Word of the Day
virgule
  • A punctuation mark (/) used to separate related items of information.
  • A little rod; a twig.
This word comes from the Late Latin 'virgula,' accentual mark, a diminutive of 'virga,' rod.
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