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Last updated on April 24, 2014 at 17:35 EDT

Latest Neurofibromin 1 Stories

2014-04-04 08:24:48

Efforts lead to the launch of Neurofibromatosis (NF) MetaMiner PHILADELPHIA, April 4, 2014 /PRNewswire/ -- The Intellectual Property & Science business of Thomson Reuters, the world's leading provider of intelligent information for businesses and professionals, today announced an expansion of its partnership with the Children's Tumor Foundation (CTF) to create unique neurofibromatosis (NF) pathway maps aimed at significantly increasing the understanding of the disease and its...

2014-02-07 13:24:38

A genetic disorder that affects about 1 in every 2,500 births can cause a bewildering array of clinical problems, including brain tumors, impaired vision, learning disabilities, behavioral problems, heart defects and bone deformities. The symptoms and their severity vary among patients affected by this condition, known as neurofibromatosis type 1 (NF1). Now, researchers at Washington University School of Medicine in St. Louis have identified a patient’s gender as a clear and simple...

2013-05-21 21:07:01

Researchers from the Masonic Cancer Center, University of Minnesota, and the University´s Brain Tumor Program, have developed a new mouse model of malignant peripheral nerve sheath tumors (MPNST) that allow them to discover new genes and gene pathways driving this type of cancer. The research was published this week in the journal Nature Genetics. Utilizing the Sleeping Beauty transposon method, researchers in the lab of David Largaespada, Ph.D., professor in the Medical School and...

2013-04-10 16:24:27

First-of-its-kind disease funding schemas provide a comprehensive view of neurofibromatosis research PHILADELPHIA, April 10, 2013 /PRNewswire/ -- The Intellectual Property & Science business of Thomson Reuters, the world's leading provider of intelligent information for businesses and professionals, today announced a partnership with the Children's Tumor Foundation (CTF), to further the understanding of neurofibromatosis (NF) research by creating schemas that visually...

Human Cancer Tumors Replicated In Mice And Then Cured
2013-03-06 09:23:12

April Flowers for redOrbit.com - Your Universe Online A group of scientists led by UT Southwestern Medical Center has reported the first successful blocking of tumor development in a genetic mouse model of an incurable human cancer. "To my knowledge, this is the first time that a mouse model of a genetically defined malignant human cancer has been generated in which the formation of the tumor from beginning to end can be monitored and in which blocking the pathway cures the mouse of the...

2012-12-24 15:13:10

The causes of learning problems associated with an inherited brain tumor disorder are much more complex than scientists had anticipated, researchers at Washington University School of Medicine in St. Louis report. The disorder, neurofibromatosis 1 (NF1), is among the most common inherited pediatric brain cancer syndromes. Children born with NF1 can develop low-grade brain tumors, but their most common problems are learning and attention difficulties. “While one of our top...

2012-12-10 12:25:10

CINCINNATI, Dec. 10, 2012 /PRNewswire-USNewswire/ -- Researchers conducting a preclinical study in mice successfully used targeted molecular therapy to block mostly untreatable nerve tumors that develop in people with the genetic disorder Neurofibromatosis 1 (NF1). (Logo: http://photos.prnewswire.com/prnh/20110406/MM79025LOGO) Scientists from Cincinnati Children's Hospital Medical Center report their findings online Dec. 10 in the Journal of Clinical Investigation. "We can for the first...

2012-11-27 15:33:43

Johns Hopkins researchers call for early and frequent screening of women with neurofibromatosis-1 New Johns Hopkins research showing a more than four-fold increase in the incidence of breast cancer in women with neurofibromatosis-1 (NF1) adds to growing evidence that women with this rare genetic disorder may benefit from early breast cancer screening with mammograms beginning at age 40, and manual breast exams as early as adolescence. In a small study of 126 women with NF1 at the Johns...

Could Learning Disabilities In Some Kids Be Prevented With Cancer Drug?
2012-08-29 11:01:08

U-M scientists stop abnormal brain cell growth in mice with neurofibromatosis using experimental tumor drug, make new discoveries in neural stem cells A drug originally developed to stop cancerous tumors may hold the potential to prevent abnormal brain cell growth and learning disabilities in some children, if they can be diagnosed early enough, a new animal study suggests. The surprising finding sets the stage for more research on how anti-tumor medication might be used to protect the...

2010-03-24 08:54:08

Researchers have discovered how a genetic disease known mainly for its life-threatening tumors also can cause sudden death from cardiovascular disease in children, and are mounting a clinical trial to develop treatments for the problem. Scientists from the Indiana University School of Medicine found that the mutation that causes neurofibromatosis type 1 disease leads to arterial inflammation and damage that is similar to the long-term damage that can occur as people age. They reported their...