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Latest Neuromuscular junction Stories

Both Brain And Muscle Require Having The Protein LRP4 For Strong Communication
2012-07-11 20:39:24

Communication between the brain and muscle must be strong for us to eat, breathe or walk. Now scientists have found that a protein known to be on the surface of muscle cells must be present in both tissues to ensure the conversation is robust. Scientists at the Medical College of Georgia at Georgia Health Sciences University have shown that without LRP4 in muscle cells and neurons, communication between the two cells types is inefficient and short-lived. Problems with the protein appear...

2012-06-07 08:33:20

Research shows mice brains are 'very wired up' at birth, and suggests experience selects which connections to keep Ask the average person the street how the brain develops, and they'll likely tell you that the brain's wiring is built as newborns first begin to experience the world. With more experience, those connections are strengthened, and new branches are built as they learn and grow. A new study conducted in a Harvard lab, however, suggests that just the opposite is true. As...

2012-02-08 14:33:52

Some unusual alliances are necessary for you to wiggle your fingers, researchers report. Understanding those relationships should enable better treatment of neuromuscular diseases, such as myasthenia gravis, which prevent muscles from taking orders from your brain, said Dr. Lin Mei, Director of the Institute of Molecular Medicine and Genetics at Georgia Health Sciences University. During development, neurons in the spinal cord reach out to muscle fibers to form a direct line of...

2011-10-31 11:26:45

Penn study in fruit flies has implications for autism, other cognitive impairment syndromes The most common form of heritable cognitive impairment is Fragile X Syndrome, caused by mutation or malfunction of the FMR1 gene. Loss of FMR1 function is also the most common genetic cause of autism. Understanding how this gene works is vital to finding new treatments to help Fragile X patients and others. Researchers from the Perelman School of Medicine at the University of Pennsylvania, and...

2011-05-25 21:30:11

With every bodily movement"”from the blink of an eye to running a marathon"”nerve cells transmit signals to muscle cells. To do that, nerve cells rely on tiny molecular motors to transport chemical messengers (neurotransmitters) that excite muscles cells into action. It's a complex process, which scientists are still trying to understand. A new study by Syracuse University researchers has uncovered an important piece of the puzzle. The study, published in the April 22 issue of...

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2011-01-31 09:21:10

Among stem cell biologists there are few better-known proteins than nestin, whose very presence in an immature cell identifies it as a "stem cell," such as a neural stem cell. As helpful as this is to researchers, until now no one knew which purpose nestin serves in a cell. In a study published in the Jan. 30, 2011, advance online edition of Nature Neuroscience, Salk Institute of Biological Studies investigators led by Kuo-Fen Lee, PhD., show that nestin has reason for being in a completely...

2010-08-03 13:15:46

Finding may illuminate a reason for the beneficial effects of these regimens on aging Harvard University researchers have uncovered a mechanism through which caloric restriction and exercise delay some of the debilitating effects of aging by rejuvenating connections between nerves and the muscles that they control. The research, conducted in the labs of Joshua Sanes and Jeff Lichtman and described this week in the journal Proceedings of the National Academy of Sciences, begins to explain...

2009-12-10 14:00:53

Findings could lead to novel therapeutic intervention strategies for neuromuscular disorders; data published in latest issue of Science  miRagen Therapeutics, Inc., a biopharmaceutical company focused on improving patients' lives by developing innovative microRNA-based therapeutics for cardiovascular and muscle disease, today announced the publication of data demonstrating that microRNA-206 (miR-206) plays a crucial role in the progression of amyotrophic lateral sclerosis (ALS or Lou...

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2009-01-05 10:28:03

Possible mechanism of muscle denervation in Emery-Dreifuss muscular dystrophy Mutations in the nuclear intermediate filament lamin A/C (LMNA) gene are associated with Emery-Dreifuss muscular dystrophy, but cause the disease by unknown mechanisms. M©jat et al. show that one mechanism involves the disruption of neuromuscular junctions. The study will appear online on Monday, January 5, 2009 and in the January 12, 2009 print issue of the Journal of Cell Biology. Muscle fiber cells contain...

2005-09-02 15:47:34

A UCSF study has found that a specific signaling link between neurons and muscles in the fruit fly is essential for keeping the insect's nervous system stable. The findings are relevant for ongoing research in identifying causes and developing treatments for neuromuscular neurodegenerative diseases in humans, such as amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, says study co-author Graeme Davis, PhD, associate professor and vice chair of the Department of...


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