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Latest Neurotransmitter transporters Stories

2013-01-23 16:24:44

SAN DIEGO, Jan. 23, 2013 /PRNewswire/ -- Neurocrine Biosciences, Inc. (NASDAQ: NBIX) announced today that two additional patents have been granted related to the Company's proprietary Vesicular Monoamine Transporter 2 inhibitor (VMAT2) NBI-98854. European Patent Number 2,081,929 was granted in January 2013 by the European Patent Office with an expiration date of November 2027. This patent covers chemical compositions, pharmaceutical compositions and uses of various compounds...

2012-10-26 00:35:45

Scientists may have discovered why the standard treatment for Parkinson's disease is often effective for only a limited period of time. Their research could lead to a better understanding of many brain disorders, from drug addiction to depression, that share certain signaling molecules involved in modulating brain activity. A team led by Bernardo Sabatini, Takeda Professor of Neurobiology at Harvard Medical School, used mouse models to study dopamine neurons in the striatum, a region of...

Glowing Molecules Help Scientists Track Serotonin
2012-07-02 10:08:10

[ Watch the Video ] John Neumann for redOrbit.com - Your Universe Online Researchers have succeeded in tracking a single protein that regulates the neurotransmitter serotonin, making it possible to study the dynamics of the protein which regulates mood, appetite and sleep, at an unprecedented level of detail, reports David Salisbury of Vanderbilt University. Attempts to understand how these transporters work have been limited by the difficulty of studying their dynamic behavior. The...

2012-03-20 16:56:28

Early disruptions in serotonin signaling in the brain may contribute to autism spectrum disorder (ASD), and other "enduring effects on behavior," Vanderbilt University researchers report. Serotonin is a brain chemical that carries signals across the synapse, or gap between nerve cells. The supply of serotonin is regulated by the serotonin transporter (SERT). In 2005, a team of Vanderbilt researchers led by Randy Blakely and James Sutcliffe identified rare genetic variations in children...

2011-10-03 13:22:38

New approach simplifies the search for more specific drugs Psychiatric ailments such as depression, obsessive-compulsive disorder or anxiety states are often associated with disturbances in the metabolism of the neurotransmitter serotonin. Neurotransmitters are compounds that are released from the synapses at nerve cell endings and activate the firing of neighboring neurons. Thus, as their name suggests, they mediate the transmission of nerve impulses. The serotonin transporter (SERT) is...

2011-04-25 13:48:15

New discoveries may lead to insights into drug abuse and depression A team of scientists from Columbia University College of Physicians and Surgeons and Weill Cornell Medical College has shed light on the molecular workings of transporter proteins, molecular machines embedded in the cell membranes of neurons that modulate the transfer of signals between cells and recycle neurotransmitters. The research, published today in the journal Nature, reveals with unprecedented detail how the molecule...

2010-06-11 01:50:29

A first view of shape-shifting movements in membrane transporters; hailed as a breakthrough in understanding membrane transport, research may lead to better treatments for depression and substance abuse In what has been hailed as a breakthrough, scientists from Columbia University Medical Center and Weill Cornell Medical College have outlined the molecular mechanism of membrane transport. The research shows how a protein transforms its shape to transport substances across the cell membrane in...

2010-04-06 07:41:46

A genetic mutation in mice elevates their risk of stress-induced depression Depression and schizophrenia can be triggered by environmental stimuli and often occur in response to stressful life events. However, some people have a higher predisposition to develop these diseases, which highlights a role for genetics in determining a person's disease risk. A high number of people with depression have a genetic change that alters a protein that cells use to talk to each other in the brain. Imaging...

2009-01-27 16:36:26

Vanderbilt University Medical Center investigators have found a surprising link between brain iron levels and serotonin, a neurotransmitter involved in neuropsychiatric conditions ranging from autism to major depression. Appearing in the Proceedings of the National Academy of Sciences this week, the study by Randy Blakely, Ph.D., and colleagues also demonstrates the utility of a powerful in silico approach for discovering novel traits linked to subtle genetic variation. The serotonin...

2008-09-10 00:00:26

Canadian researchers have found they can use positron emission tomography, or PET scans, to detect seasonal variations in brain chemical transport. Dr. Jeffrey Meyer of the Centre for Addiction and Mental Health in Toronto led a team of researchers who determined the variations in how much serotonin -- a brain chemical involved in regulating physical functions such as eating and energy balance -- is removed via serotonin transporter binding in the living brain can be correlated with the...