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Latest Neurotrophin Stories

2012-01-27 15:31:55

The research, published in Neuroscience, sheds light on what determines availability of the molecules involved in cardiorespiratory control Researchers at Oregon Health & Science University (http://www.ohsu.edu) have discovered that a molecule critical to the development and plasticity of nerve cells — brain-derived neurotrophic factor (BDNF) -- is severely lacking in brainstem neurons in mutations leading to Rett syndrome, a neurological developmental disorder. The finding has...

2011-12-06 11:21:42

Results published in the American Journal of Pathology Laquinimod is an orally available synthetic compound that has been successfully evaluated in phase II/III clinical studies for the treatment of relapsing-remitting multiple sclerosis (RRMS). The mechanism of action of laquinimod has not been fully elucidated, but a study published in the January 2012 issue of The American Journal of Pathology suggests that laquinimod triggers immune cells within the central nervous system to produce...

2011-08-16 12:40:26

    * Brain-derived neurotrophic factor (BDNF) regulates neuronal plasticity.    * Researchers have found high serum BDNF levels among alcohol-dependent (AD) but abstinent individuals that do not correlate with either chronic drinking or associated toxicity.    * These findings suggest that BDNF may predict relapse in AD individuals undergoing treatment. One of the ways an alcohol dependence (AD) diagnosis can be made is through measurement of...

2011-07-20 17:01:08

Dr. Ed Ruthazer is a mapmaker but, his landscape is the developing brain - specifically the neuronal circuitry, which is the network of connections between nerve cells. His research at The Montreal Neurological Institute and Hospital "“ The Neuro at McGill University, reveals the brain as a dynamic landscape where connections between nerves are plastic, changing and adapting to the demands of the environment. Dr. Ruthazer is the winner of the inaugural Young Investigator Award from the...

2011-04-18 21:10:16

An estimated 19 million Americans suffer from depression, and though the symptoms might be recognizable, the brain chemistry that underlies them is incompletely understood. Research suggests that aberrant signaling by a chemical called Brain-Derived Neurotrophic Factor (BDNF) through its receptor TrkB, may contribute to anxiety and depression, and inhibiting this pathway in mice can reduce anxiety and depression-related behaviors. However, translating these findings to clinical studies will...

2011-02-09 06:30:00

RESEARCH TRIANGLE PARK, N.C., Feb. 9, 2011 /PRNewswire/ -- CeNeRx BioPharma, Inc., a clinical-stage company developing and commercializing innovative treatments for diseases of the central nervous system (CNS), today announced FDA approval of its IND and reported the first clinical results in humans for CXB909, a novel agent that has demonstrated utility in preclinical models of neuroprotection and neurodegenerative disorders. CXB909 is a small molecule, orally active agent that...

2010-06-22 11:00:00

NEW YORK, June 22 /PRNewswire-USNewswire/ -- The Michael J. Fox Foundation for Parkinson's Research today announced $4.6 million in awards to support two promising studies of neurotrophic factor therapies for Parkinson's disease. The projects, funded under a directed LEAPS (Linked Efforts to Accelerate Parkinson's Solutions) initiative, bring together leading investigators to build on the knowledge and experience gained from previous trials of neurotrophic factors to help speed this...

2010-03-12 09:20:53

The research, published in the Journal of Neuroscience Research, sheds light on what determines availability of the molecules involved in blood pressure control Researchers at Oregon Health & Science University's School of Dentistry have discovered that nitric oxide is a powerful regulator of a molecule that plays a critical role in the development and function of the nervous system. The finding could someday play a significant role in the prevention and treatment of high blood pressure,...

2010-02-04 22:16:08

Scientists at Emory University School of Medicine have discovered unexpected properties for a precursor to melatonin, the hormone that regulates sleep cycles. Melatonin is produced from the neurotransmitter serotonin in a daily rhythm that peaks at night. Melatonin's immediate precursor, N-acetylserotonin, was not previously thought to have effects separate from those of melatonin or serotonin. Now an Emory team has shown that N-acetylserotonin can stimulate the same circuits in the brain...

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2010-01-27 14:41:56

Draw a map of the brain when fear and anxiety are involved, and the amygdala"”the brain's almond-shaped center for panic and fight-or-flight responses"”looms large. But the amygdala doesn't do its job alone. Scientists at Emory University have recently built upon work from others, extending the fear map to part of the brain known as the prelimbic cortex. Researchers led by Kerry Ressler, MD, PhD, found that mice lacking a critical growth factor in the prelimbic cortex have trouble...


Word of the Day
ramage
  • Boughs or branches.
  • Warbling of birds in trees.
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