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Latest Neurotrophin Stories

2010-01-26 12:16:21

Researchers have identified a compound that mimics one of the brain's own growth factors and can protect brain cells against damage in several animal models of neurological disease. 7,8-dihydroxyflavone is a member of the flavonoid family of chemicals, which are abundant in fruits and vegetables. The compound's selective effects suggest that it could be the founder of a new class of brain-protecting drugs. The results were published online this week in the Proceedings of the National Academy...

2010-01-20 13:37:06

2 major studies in 2 months make a new case for an old suspect in the mystery of how memory works A second high-profile paper in as many months has found an important role in learning and memory for calpain, a molecule whose academic fortunes have ebbed and flowed for 25 years. USC's Michel Baudry (then at the University of California, Irvine) and Gary Lynch (UC Irvine) first pointed to calpain as the key to memory in a seminal 1984 paper in Science on the biochemistry of memory. In a paper...

2009-12-09 19:44:52

Cells release nourishing growth factor in key area Nerve cells transplanted into brain-damaged rats helped them to fully recover their ability to learn and remember, probably by promoting nurturing, protective growth factors, according to a new study. Building on previous investigation of transplants in the nervous system, this critical study confirms that cell transplants can help the brain to heal itself. Ultimately, it may lead to new therapies to help dementia patients. More generally,...

2009-09-21 09:21:51

An investigative drug deprived non-Hodgkin lymphoma cells of their ability to survive too long and multiply too fast, according to an early study published recently in the journal Experimental Hematology. To function normally, the cells that make up bodily tissues must "decide" when to divide and multiply (proliferate) and when to die. Cell death restricts the human cell population as a counterbalance to growth, and billions of cells must die each year just to hold the number constant. Cell...

2009-07-21 14:02:57

UC Irvine scientists have shown for the first time that neural stem cells can rescue memory in mice with advanced Alzheimer's disease, raising hopes of a potential treatment for the leading cause of elderly dementia that afflicts 5.3 million people in the U.S.Mice genetically engineered to have Alzheimer's performed markedly better on memory tests a month after mouse neural stem cells were injected into their brains. The stem cells secreted a protein that created more neural connections,...

2009-06-16 06:55:00

--Orally Active Enhancer of Human Nerve Growth Factor Has Demonstrated Promising Activity Preclinically-- --Broad Potential Applications Include Neuropathies, Alzheimer's and Huntington's Disease and Others-- RESEARCH TRIANGLE PARK, N.C., June 16 /PRNewswire/ -- CeNeRx BioPharma, Inc., a clinical stage company developing and commercializing innovative treatments for diseases of the central nervous system (CNS), today announced that it has obtained the rights to develop and market a novel...

2009-02-02 13:15:00

Weill Cornell Medical College study could lead to better understanding of memory formation New research sheds light on a neural growth factor called proBDNF, finding that it is present and potentially active during the perinatal period when the brain's circuitry and memory-encoding regions are being refined. Led by Weill Cornell Medical College investigators with those at the National Institutes of Health (NIH) and Memorial Sloan-Kettering Cancer Center (MSKCC), and reported in the Jan....

2009-01-09 08:58:40

Researchers at Oregon Health & Science University's School of Dentistry (www.ohsu.edu/sod) have discovered that the nerve cells controlling heart rate and blood pressure synthesize a molecule known to be critically important for proper nervous system growth. The finding could someday play a significant role in the prevention of Sudden Infant Death Syndrome (SIDS) and high blood pressure. According to the National Institutes of Health, SIDS is the leading cause of death in children between...

2008-11-19 17:01:40

In a study in mice, exercise was found to reverse the age-related decline in the production of neural stem cells in the brain, scientists in Taiwan said. The researchers at the National Cheng Kung University Medical College suggest exercise promotes the production and maturation of new stem cells by helping restore a brain chemical known as neurotrophic factor and its receptor, TrkB. When fewer new stem or progenitor cells are produced in the hippocampus -- a part of the brain which plays an...

2008-09-03 12:00:00

U.S. scientists say they've discovered deep brain stimulation, a surgical procedure used in Parkinson's disease, halts dopamine-cell loss in animal models. Researchers at the University of Cincinnati's Neuroscience Institute posit the act of stimulating neurons with electrodes boosted the amount of an important protein in animals' brains. The protein, a trophic factor known as brain-derived neurotrophic factor, is a nurturing, growth-promoting chemical. Parkinson's disease is a degenerative...


Word of the Day
reremouse
  • A bat.
The word 'reremouse' comes from Middle English reremous, from Old English hrēremūs, hrērmūs ("bat"), equivalent to rear (“to move, shake, stir”) +‎ mouse.
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