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Latest New England Journal Stories

2013-03-21 10:12:50

Long-term follow-up of a phase II study from KEMRI-Wellcome Trust Research Programme and Oxford University researchers in Kenya shows that the efficacy of a malaria vaccine candidate, RTS,S, wanes over time and varies with exposure to the malaria parasite. The findings will help to inform which populations are likely to benefit most from the vaccine candidate. They also have important implications for the design of future clinical trials of this and other vaccine candidates and highlight...

2013-03-14 17:23:00

When someone has a stroke, time equals brain. The longer a stroke is left untreated, the more brain tissue is lost. Since the only proven treatment – a clot-busting drug – works in less than half of patients, stroke physicians had high hopes for a mechanical device that could travel through the blocked blood vessel to retrieve or break up the clot, restoring blood flow to the brain. But in a recently completed multi-site trial in which UCLA served as the clinical coordinating...

2013-03-11 15:08:13

Phase 3 findings published in NEJM provide answers about treatment with darbepoetin alfa Researchers from Cleveland Clinic and Sweden-based Sahlgrenska University Hospital have found that a commonly used drug to treat anemia in heart failure patients —darbepoetin alfa — does not improve patients' health, nor does it reduce their risk of death from heart failure. Results of the international study were presented at the American College of Cardiology's annual meeting in San...

2013-03-07 23:56:50

Different priorities from physicians, patients weaken opportunities for genuine reform The wide consensus that health care spending poses a threat to the nation's fiscal solvency has led to the championing of "value" as a goal of health care reform efforts. But the divergence of opinions between patients and physicians on the meaning of value presents an obstacle to progress in achieving genuine reform, says Lisa Rosenbaum, MD, a Robert Wood Johnson Foundation Clinical Scholar and...

2013-03-07 23:55:16

As baby-boomers age and the number of people with serious chronic illnesses continues to rise, the demand for experts in palliative medicine is sure to outstrip the supply, according Timothy E. Quill, M.D., professor of Medicine, Psychiatry and Medical Humanities in the Center for Ethics, Humanities and Palliative Care at the University of Rochester Medical Center. In a perspective published in today's New England Journal of Medicine, Quill, who serves as president of the American Academy...

2013-02-07 12:24:59

Researchers have discovered a gene associated with a form of cholesterol that increases the risk of developing aortic stenosis, the most common form of heart valve disease, by more than half. This international study, involving the Research Institute of the McGill University Health Centre (RI-MUHC), is the first of its kind to uncover a genetic link with aortic valve disease — a condition that affects more than 5 million people in North America. The results of the study, published in...

2013-02-07 12:22:59

Study described in the New England Journal of Medicine is the first to show cause-and-effect relationship between a gene variant and calcium deposits on the aortic valve Researchers have found a genetic variant that doubles the likelihood that people will have calcium deposits on their aortic valve. Such calcification, if it becomes severe, can cause narrowing or a blockage of the aortic valve, a condition called aortic stenosis. The study is the first large-scale, genome-wide association...

2013-02-07 12:21:01

An international collaboration of researchers from the U.S. Army Medical Research and Materiel Command (USAMRMC), Tunisia and France has demonstrated a high cure rate and remarkably few side effects in treating patients with cutaneous leishmaniasis (CL) with an investigational antibiotic cream. CL is a parasitic disease that causes disfiguring lesions, with 350 million people at risk worldwide and 1.5 million new cases annually, including U.S. military personnel serving abroad and the...

2013-01-23 10:49:40

Commentary sheds light on approval process for implantable body parts Technological advancements in medicine have allowed patients suffering from musculoskeletal conditions such as hip and knee pain to regain mobility and live relatively pain-free. But some "high risk" surgical devices that have been approved by the U.S. Food and Drug Administration (FDA) are not required to go through clinical trials, where a product is tested to determine its safety and effectiveness. "This could be...

2013-01-17 13:44:36

Teams using checklists were 74 percent less likely to miss key life-saving steps in care during emergency situations than those working from memory alone In an airplane crisis–an engine failure, a fire–pilots pull out a checklist to help with their decision-making. But in an operating room crisis–massive bleeding, a patient's heart stops–surgical teams don't. Given the complexity of judgment and circumstances, standard practice is for teams to use memory alone. In a...


Word of the Day
holluschickie
  • A 'bachelor seal'; a young male seal which is prevented from mating by its herd's older males (mated bulls defending their territory).
This comes from the Russian word for 'bachelors.'
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