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Latest NF-κB Stories

2013-01-04 11:02:11

Researchers at Mayo Clinic in Florida have identified a new target to improve treatment of pancreatic ductal adenocarcinoma cancer, which accounts for more than 95 percent of pancreatic cancer cases. This fast-growing, often lethal cancer is resistant to conventional chemotherapy. The findings are published in the Jan. 3 online issue of PLOS ONE. The researchers decoded a molecular pathway that is switched "on" at all times, promoting accelerated growth of pancreatic tumors, and that...

2012-11-21 06:20:29

This discovery holds the potential to reduce healthcare costs for many common inflammatory diseases such as cancer and diabetesSingapore, Nov 21, 2012 - (ACN Newswire) - A*STAR scientists have identified the enzyme, telomerase, as a cause of chronic inflammation in human cancers. Chronic inflammation is now recognized as a key underlying cause for the development of many human cancers, autoimmune disorders, neurodegenerative diseases, and metabolic diseases such as diabetes. This enzyme,...

Loneliness Decreases In Adults Who Use Meditation
2012-08-15 12:59:06

Connie K. Ho for redOrbit.com — Your Universe Online Loneliness cannot only be damaging for the psyche, but also has physical impacts. Researchers from the University of California, Los Angeles (UCLA) found that a meditation program, completed in a little less than eight weeks, helped decrease loneliness among adults. The UCLA study also finds that mindfulness can also help boost the immune system. The findings, featured in a recent online edition of the journal Brain, Behavior...

2012-07-31 12:27:31

During Alzheimer's disease, 'plaques' of amyloid beta (Ab) and tau protein 'tangles' develop in the brain, leading to the death of brain cells and disruption of chemical signaling between neurons. This leads to loss of memory, mood changes, and difficulties with reasoning. New research published in BioMed Central's open access journal Alzheimer's Research & Therapy, has found that up-regulating the gene Hes1 largely counteracted the effects of Ab on neurons, including preventing cell...

2012-06-19 23:50:48

Researchers at the IMIM (Institut de Recerca Hospital del Mar) have proven that the absence of the 14-3-3 protein sigma in breast cancer cells is directly associated with these cells´ capacity to activate the signalling of a protein complex called NF-kB, which is related to tumor progression. The activation of NF-kB in tumors was also identified as the best indicator for relapse in breast cancer patients, compared to other parameters currently used, such as the presence of affected...

2012-05-24 22:00:51

Acute inflammatory diseases, such as sepsis, as well as chronic inflammatory diseases like diabetes and arthritis, develop as a result of sustained inflammation of the blood vessel wall. Researchers at Brigham and Women's Hospital (BWH) have discovered that a microRNA (small, non-coding RNA molecule) called miR-181b can reduce the inflammatory response that is responsible for such diseases. The findings, by researchers led by Mark Feinberg, MD from BWH and Harvard Medical School, will pave...

2012-05-16 22:24:14

Scientists optimistic that targeting pathway's cellular transcription process will lead to death of multiple myeloma cells Researchers at NYU School of Medicine have identified a target for slowing the progression of multiple myeloma by using currently available drugs. Published recently in Nature Cell Biology, the study reveals a pathway that, if deactivated, may help slow the development of the disease. "We have the ability to target this pathway with drugs that already exist,"...

2012-03-14 09:33:42

Discovered the molecular mechanism responsible for vertebral column degeneration Italian researchers at the Catholic University of Sacred Heart in Rome found an important molecular mechanism responsible for low back pain and other acute vertebral problems like cervical axial pain, all due to aging and degeneration of the vertebral column. The team led by Dr. Luigi Aurelio Nasto and Enrico Pola also developed an experimental drug to inhibit this degenerative mechanism, by blocking its...


Word of the Day
negawatt
  • A unit of saved energy.
Coined by Amory Lovins, chairman of the Rocky Mountain Institute as a contraction of negative watt on the model of similar compounds like megawatt.