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Latest NF-κB Stories

2009-09-22 08:00:29

Researchers have identified a mechanism that may keep a well known signaling molecule from eroding bone and inflaming joints, according to an early study published online today in the Journal of Clinical Investigation. Bone is continually recycled to maintain its strength through the competing action of osteoclasts, cells that break down aging bone, and osteoblasts, which build new bone. Osteoclasts also play a central role in common diseases that erode bone, where two signaling molecules,...

2009-05-19 08:44:23

Inhibiting key protein restores balance between bone formation, resorption Osteoporosis and periodontitis are common diseases whose sufferers must cope with weakness, injury and reduced function as they lose bone more quickly than it is formed. While the mechanism of bone destruction in these diseases is understood, scientists have had less information about how bone formation is impaired. Now, researchers at the UCLA School of Dentistry, working with scientists at the University of Michigan...

2009-04-21 22:14:46

An anti-inflammatory herbal extract may inhibit pancreatic cancer, U.S. researchers say. Thymoquinone -- the major constituent of the oil extract from a Middle Eastern herbal seed called Nigella sativa used as a traditional medicinal in Middle Eastern and Asian countries -- reduces the release of inflammatory mediators in pancreatic cancer cells. Dr. Hwyda Arafat of the Jefferson Medical College of Thomas Jefferson University in Philadelphia, who was the study leader, says thymoquinone...

2009-04-19 09:39:39

An herb recently found to kill pancreatic cancer cells also appears to inhibit development of pancreatic cancer as a result of its anti-inflammatory properties, according to researchers from the Kimmel Cancer Center at Jefferson. The data were presented at the AACR 100th Annual Meeting 2009 in Denver. (Abstract #494)Thymoquinone, the major constituent of the oil extract from a Middle Eastern herbal seed called Nigella sativa, exhibited anti-inflammatory properties that reduced the release of...

2009-04-10 08:13:28

A study published tomorrow (10 April) in Science examines a key player in conditions such as cancer, inflammatory bowel disease, rheumatoid arthritis and asthma and has shown that cells use a sophisticated communication system to coordinate responses to infection and maintain inflammation in the body. This system is now a target for designing drugs to treat these conditions.Scientists funded by the Biotechnology and Biological Sciences Research Council (BBSRC), the Medical Research Council...

2009-04-01 18:29:14

A biological indicator has been found that may help identify which brain-cancer patients have the most aggressive forms of the disease, U.S. researchers say. Dr. Amyn Habib of the University of Texas Southwestern Medical Center and colleagues found that an inflammation-related molecule called RIP1 is commonly found in high levels in glioblastoma, the most common primary malignant brain tumor in adults. The protein RIP1 is a component of the complex NF-kB signaling network -- a family of...

2009-03-11 11:12:51

U.S. biochemists say they've identified a new pathway that controls the activity of a protein involved in inflammation regulation. University of Illinois Professor Lin-Feng Chen and colleagues said their findings could have important implications for the treatment of diseases or conditions linked to chronic inflammation. The researchers said they have deciphered a molecular code that controls the function of a protein complex called NF-kappa B that is involved in a cell's inflammatory...

2008-10-03 03:00:06

A NEWLY-discovered 'weight gain' pathway in the brain could hold the key to tackling obesity. Research shows a protein, called NF-kappaB, which is found in the hypothalamus may encourage a build up of fat. It is usually inactive, but over-eating can activate it. Scientists at the University of Wisconsin-Madison suggest that the protein could be blocked by drugs, and so reduce obesity levels. (c) 2008 Daily Record; Glasgow (UK). Provided by ProQuest LLC. All rights Reserved.

2008-04-16 15:04:10

Salmonella are wily and obnoxious bacterial invaders--escape artists capable of evading multiple immune responses and causing a harsh and debilitating intestinal infection.Researchers have come closer to understanding how these bacteria manage to thwart two major categories of immune defenses at once and set up shop in a host organism. New results are reported in the April 2008 issue of the journal Cell Host & Microbe.The Emory University research team used a transgenic fruit fly...

2006-04-08 10:33:24

(RedOrbit) It is widely known that one drawback of current cancer treatments is that while tumor cells are targeted and killed, some healthy cells may also be killed in the process. Researchers are looking for ways to more effectively target cancer cells without harming their healthy neighbors, a process know as targeted therapy. Three candidates for targeted therapies are highlighted below. NF-kB Researchers from the National Cancer Institute (NCI) in Bethesda, Md., have found they may be...


Word of the Day
baudekin
  • A rich embroidered or brocaded silk fabric woven originally with a warp of gold thread.
'Baudekin' seems to be an alternative form of 'baldachin,' from the Italian 'Baldacco,' Baghdad, the city where the material was made.
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