Latest NF-κB Stories
A biological indicator has been found that may help identify which brain-cancer patients have the most aggressive forms of the disease, U.S. researchers say. Dr. Amyn Habib of the University of Texas Southwestern Medical Center and colleagues found that an inflammation-related molecule called RIP1 is commonly found in high levels in glioblastoma, the most common primary malignant brain tumor in adults. The protein RIP1 is a component of the complex NF-kB signaling network -- a family of...
U.S. biochemists say they've identified a new pathway that controls the activity of a protein involved in inflammation regulation. University of Illinois Professor Lin-Feng Chen and colleagues said their findings could have important implications for the treatment of diseases or conditions linked to chronic inflammation. The researchers said they have deciphered a molecular code that controls the function of a protein complex called NF-kappa B that is involved in a cell's inflammatory...
A NEWLY-discovered 'weight gain' pathway in the brain could hold the key to tackling obesity. Research shows a protein, called NF-kappaB, which is found in the hypothalamus may encourage a build up of fat. It is usually inactive, but over-eating can activate it. Scientists at the University of Wisconsin-Madison suggest that the protein could be blocked by drugs, and so reduce obesity levels. (c) 2008 Daily Record; Glasgow (UK). Provided by ProQuest LLC. All rights Reserved.
Salmonella are wily and obnoxious bacterial invaders--escape artists capable of evading multiple immune responses and causing a harsh and debilitating intestinal infection.Researchers have come closer to understanding how these bacteria manage to thwart two major categories of immune defenses at once and set up shop in a host organism. New results are reported in the April 2008 issue of the journal Cell Host & Microbe.The Emory University research team used a transgenic fruit fly...
(RedOrbit) It is widely known that one drawback of current cancer treatments is that while tumor cells are targeted and killed, some healthy cells may also be killed in the process. Researchers are looking for ways to more effectively target cancer cells without harming their healthy neighbors, a process know as targeted therapy.Three candidates for targeted therapies are highlighted below. NF-kBResearchers from the National Cancer Institute (NCI) in Bethesda, Md., have found they may be able...
San Francisco, Calif. (December 1, 2005)-- Researchers at the Gladstone Institute of Neurological Disease have identified a potential new way to stop brain cell death related to Alzheimer's disease. Working with cell cultures, the scientists investigated how amyloid beta proteins, which build up in the brain tissue of people with Alzheimer's disease, kill neurons. The cell cultures were established from brain tissue of laboratory rats. Study findings showed that amyloid beta could be...
The bronchial tubes of a patient with severe asthma can become scarred due to repeated episodes of allergic inflammation in the airways. The scarring results in blocked airways, excessive production of mucus, and shortness of breath.Researchers at the University of California, San Diego (UCSD) School of Medicine have discovered that when a single gene "“ IKK beta "“ is selectively inactivated in the membrane-lining cells of the bronchial tubes of mice that later inhale allergens, such...
Aug. 9, 2005 "” Scientists have used a glowing protein from fireflies to observe the activity of a molecule that is an important target for new drugs to treat cancer, autoimmune diseases and several other disorders. The target molecule, known as IKK (for IKappa kinase), regulates processes that can trigger dramatic changes in cellular physiology. Scientists have linked these changes to many different disorders. "Our new system allows researchers to monitor whether drugs for these...
