Latest Nicotinic acetylcholine receptor Stories
Researchers describe their scientific presentations for neuroscience 2010Researchers from Georgetown University Medical Center's departments of neuroscience, pharmacology, physiology, biochemistry, molecular and cellular biology, and the interdisciplinary program of neuroscience will present more than 50 research abstracts at the 40th Annual Meeting of the Society for Neuroscience Nov. 13th through the 17th in San Diego.Modulation of temporal relationships between default mode and...
NESS ZIONA, Israel, November 9, 2010 /PRNewswire/ -- NeuroDerm, Ltd. announced today that patient enrollment has begun in a Phase 2a clinical study of ND0801, a new product for the treatment of Attention Deficit Disorder/Attention Deficit Hyperactivity Disorder (ADD/ADHD) in adults. ND0801, based on a new, proprietary combination with nicotinic actions, is being developed as a dermal patch and will be evaluated for the treatment of cognitive impairment in several disorders including...
WATERTOWN, Mass., Nov. 5, 2010 /PRNewswire/ -- EnVivo Pharmaceuticals today announced it has discovered that EVP-6124, its alpha-7 nicotinic acetylcholine receptor agonist, possesses a novel mechanism not previously seen in the scientific community: it acts as a co-agonist with Acetylcholine (ACh) to enhance cognition. By acting as a co-agonist and sensitizing the alpha-7 receptor, EVP-6124 makes it possible for smaller amounts of naturally occurring ACh, typically found in individuals with...
Stimulating the brain's Alpha7 nicotine receptor may eliminate side effects caused by promising Alzheimer's drugA team of neuroscientists has discovered important new information in the search for an effective treatment for Alzheimer's disease, the debilitating neurological disorder that afflicts more than 5.3 million Americans and is the sixth-leading cause of death in the United States. Hey-Kyoung Lee, associate professor in the University of Maryland Department of Biology, and her research...
When nicotine binds to the nicotinic acetylcholine receptor (nAchR), it is known to promote smoking addiction and may also directly promote the development of breast cancer, according to a study published online August 23 in The Journal of the National Cancer Institute.While smoking is a well-known risk factor for a broad range of cancer types, non-nicotine components of tobacco have generally been thought to be the carcinogens, so little is known about how nicotine acts on cells to promote...
NEW YORK, Oct. 26 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue. Reportlinker Adds Ion Channel Modulator Pipelines: Targets and Agents in Development http://www.reportlinker.com/p0156556/Reportlinker-Adds-Ion-Channel-Modulator-Pipelines-Targets-and-Agents-in-Development.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=prnewswire Ion channels represent a significant opportunity to address an underexploited class of...
Barrow Neurological Institute researchers have identified a novel receptor in the brain that is extremely sensitive to beta-amyloid peptide (AB) and may play a key role in early stages of Alzheimer's disease.Published in the Journal of Neuroscience, the research lead by Jie Wu, MD, PhD, has identified a new candidate for therapeutic intervention in Alzheimer's.The novel receptor was found in the basal forebrain, an area of the brain that plays a critical role in memory and learning and is one...
WATERTOWN, Mass., July 7 /PRNewswire/ -- WHAT: EnVivo Pharmaceuticals to share results from its Ib/IIa trial in Alzheimer's disease patients with its nicotinic alpha-7 agonist EVP-6124. WHEN: Wednesday, July 15, 2009. WHERE: Alzheimer's Association 2009 International Conference on Alzheimer's Disease (ICAD) in Vienna, Austria. WHO: Dana Hilt, MD, senior vice president,...
Nicotine isn't just addictive, it may also interfere with dozens of cellular interactions in the body, U.S. researchers suggest. Brown University researchers say the data could help scientists develop better treatments for various diseases. It opens several new lines of investigation, lead author Edward Hawrot says in a statement. Hawrot and a team that included graduate students William Brucker and Joao Paulo looked specifically at the alpha-7 nicotinic acetylcholine receptor in mouse brain...
Scientists have identified a relationship between two proteins in the brain that has links to both nicotine addiction and autism. The finding has led to speculation that existing drugs used to curb nicotine addiction might serve as the basis for potential therapies to alleviate the symptoms of autism.The discovery identified a defining role for a protein made by the neurexin-1 gene, which is located in brain cells and assists in connecting neurons as part of the brain's chemical communication...
