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Latest NOD2 Stories

2014-09-18 08:29:39

MILFORD, Mass., Sept. 18, 2014 /PRNewswire/ -- Spring Bank Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company developing novel therapeutics for the treatment of RNA viruses, today announced a research collaboration with the National Institutes of Health (NIH) for animal testing of the Company's lead compound, SB 9200, against multiple viral pathogens, classified as "Special Pathogens," against which currently there are no effective antiviral therapies. SB 9200, derived...

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2014-07-20 10:59:47

Tracey Bryant, University of Delaware University of Delaware researchers have identified a protein, hiding in plain sight, that acts like a bodyguard to help protect and stabilize another key protein, that when unstable, is involved in Crohn’s disease. The fundamental research points to a possible pathway for developing an effective therapy for the inflammatory bowel disease. The research, by Catherine Leimkuhler Grimes, assistant professor of chemistry and biochemistry at UD, and...

2011-12-08 23:38:45

Three new locations for Crohn's Disease genes have been uncovered by scientists at UCL using a novel gene mapping approach. The complex genetic and environmental causes of Crohn's Disease (CD) have long been difficult to untangle. CD, a type of Inflammatory Bowel Disease that affects about 100 to 150 people per 100,000 in Europe, is characterised by inflammation in the gastrointestinal tract. Even though twin and family studies suggest a high heritability for CD of 50-60%, so far the...

2010-12-01 13:15:22

Case Western Reserve School of Medicine researchers identify new avenue for gene targeting A new finding out in the December 1st issue of Genes & Development offers insight into a new treatment avenue for two painful inflammatory diseases: Crohn's Disease and sarcoidosis. While the loss of NOD2, the gene studied in the provoking article, increases the risk of developing Crohn's disease, increased activity of this gene is also thought to exacerbate symptoms. Additionally, activating NOD2...

2010-01-27 11:18:48

Canadian research team publishes findings in Journal of Biological Chemistry A new study has found that Vitamin D, readily available in supplements or cod liver oil, can counter the effects of Crohn's disease. John White, an endocrinologist at the Research Institute of the McGill University Health Centre, led a team of scientists from McGill University and the Universit© de Montr©al who present their findings about the inflammatory bowel disease in the latest Journal of Biological...

2009-10-20 06:00:00

SAN DIEGO, Oct. 20 /PRNewswire/ -- Prometheus Laboratories Inc., a specialty pharmaceutical and diagnostic company, today announced that it has been awarded U.S. Patent No. 7,592,437 by the U.S. Patent and Trademark Office. The patent, entitled "Genes Involved in Intestinal Inflammatory Diseases and Use Thereof," covers genes useful in the detection of inflammatory diseases, including NOD2 (also known as CARD15) gene mutations which are associated with susceptibility to Crohn's...

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2009-08-23 13:14:57

Mice lacking sensor have shorter survival A cellular molecule that not only can sense two common respiratory viruses but also can direct cells to mount a defense has been identified by microbiologists at The University of Texas Health Science Center at San Antonio. The finding, published online Sunday, Aug. 23, by the journal Nature Immunology, could lead to new therapies for human respiratory syncytial virus (RSV) and influenza A (commonly known as flu), both of which are serious threats to...

2009-07-14 05:33:44

Researchers from Case Western Reserve University School of Medicine have identified a novel link between a gene known to regulate inflammation in the body and another gene which causes the majority of Crohn's Disease diagnoses. When the ITCH gene, which regulates inflammation in the body, malfunctions, it causes widespread inflammatory diseases, including inflammatory bowel disease, gastritis, uncontrolled skin inflammation, and pulmonary pneumonitis. Derek Abbott, M.D., Ph.D., assistant...

2009-07-09 09:40:00

An innovative study at the Research Institute of the MUHC has brought us closer to an explanation for Crohn's diseaseTwenty-five per cent of Crohn's disease patients have a mutation in what is called the NOD2 gene, but it is not precisely known how this mutation influences the disease. The latest study by Dr. Marcel Behr, of the Research Institute of the MUHC and McGill University, has provided new insight into how this might occur. The study will be published on July 9th in the Journal of...


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