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Latest Nuclear envelope Stories

2012-05-10 23:14:49

Ribonucleoprotein granules exit the nucleus via a budding mechanism akin to herpes-type viruses The movement of genetic materials, such as RNA and ribosomes, from the nucleus to the cytoplasm is a critical component in a cell's ability to make the proteins necessary for essential biological functions. Until now, it was believed the nuclear pore complex was the sole pathway between the cell nucleus and cytoplasm for these materials. New evidence published in Cell by Vivian Budnik, PhD,...

2011-11-18 07:08:12

Stowers researchers gain new insight into the chromosome separation process Each time a cell divides -- and it takes millions of cell divisions to create a fully grown human body from a single fertilized cell -- its chromosomes have to be accurately divvied up between both daughter cells. Researchers at the Stowers Institute for Medical Research used, ironically enough, the single-celled organism Saccharomyces cerevisiae -- commonly known as baker's yeast -- to gain new insight into the...

2011-09-14 22:11:45

Pulling the tail of mutated protein could help illuminate problems with misfolding Researchers at MIT and Carnegie Mellon University are using both civil engineering and bioengineering approaches to study the behavior of a protein associated with progeria, a rare disorder in children that causes extremely rapid aging and usually ends in death from cardiovascular disease before age 16. The disease is marked by the deletion of 50 amino acids near the end of the lamin A protein, which helps...

2010-10-14 14:56:38

Proteins that import structural material and that regulate the import determine cell size Size matters when it comes to the nucleus of a cell, and now scientists have discovered the signals that control how big the nucleus gets. Nuclear size varies not only among different species, but also in different types of cells in the same species and at different times during development. In addition, cancer cells are known to develop larger nuclei as they become more malignant. Screening for cervical...

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2010-06-11 07:03:10

Nuclear pores are the primary gatekeepers mediating communication between a cell's nucleus and its cytoplasm. Recently these large multiprotein transport channels have also been shown to play an essential role in developmental gene regulation. Despite the critical role in nuclear function, however, nuclear pore complexes remain somewhat shadowy figures, with many details about their formation shrouded in mystery. Now a team of investigators from the Salk Institute for Biological Studies has...

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2010-02-04 14:46:48

Nuclear pore complexes are best known as the communication channels that regulate the passage of all molecules to and from a cell's nucleus. Researchers at the Salk Institute for Biological Studies, however, have shown that some of the pores' constituent proteins, called nucleoporins, pull double duty as transcription factors regulating the activity of genes active during early development. This is the first time nucleoporins' gene regulatory function has been demonstrated in multicellular...

2009-12-02 13:00:59

It turns out that wearing a cap is good for you, at least if you are a mammal cell. Researchers from the Johns Hopkins Engineering in Oncology Center have shown that in healthy cells, a bundled "cap" of thread-like fibers holds the cell's nucleus, its genetic storehouse, in its proper place. Understanding this cap's influence on cell and nuclear shape, the researchers say, could provide clues to the diagnosis and treatment of diseases such as cancer, muscular dystrophy and the...

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2009-11-14 07:49:18

Meiosis "“ the pairing and recombination of chromosomes, followed by segregation of half to each egg or sperm cell "“ is a major crossroads in all organisms reproducing sexually. Yet, how the cell precisely choreographs these chromosomal interactions is a long-standing question. New findings by University of California, Berkeley, scientists show that the cell's cytoskeleton, which moves things around in the cell, plays a critical role, essentially reaching into the nucleus to...

2009-10-06 15:10:30

When it comes to the two basic types of cells, prokaryotes and eukaryotes, compartmentalization is everything. Prokaryotes are evolutionarily ancient cells that only have a membrane surrounding their outer boundary, while the more complex eukaryotes have an outer membrane and membrane bound compartments within the cell. Perhaps most notable is the double layered membrane that surrounds the nucleus, the cellular compartment which houses the cell's genetic material. The genetic material is very...

2009-06-08 08:30:24

Similar architecture of an essential nuclear pore complex module and cell's vesicle coats supports common evolutionary originThe genome of complex organisms is stashed away inside each cell's nucleus, a little like a sovereign shielded from the threatening world outside. The genome cannot govern from its protective chamber, however, without knowing what's going on in the realm beyond and having the ability to project power there. Guarding access to the nuclear chamber is the job of large,...


Word of the Day
barratry
  • The offense of persistently instigating lawsuits, typically groundless ones.
  • An unlawful breach of duty on the part of a ship's master or crew resulting in injury to the ship's owner.
  • Sale or purchase of positions in church or state.
This word ultimately comes from the Old French word 'barater,' to cheat.
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