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Latest Nuclear receptor Stories

2012-05-01 21:29:22

The candy bar you swallowed right before jumping on your bicycle keeps you going only so long before the muscles in your legs and hips reach for something with more power — the long chain fatty acids stored to keep you moving for hours. In a report in the journal Cell Metabolism, Dr. Bert O'Malley, professor and chair of molecular and cellular biology at Baylor College of Medicine, Dr. Brian York, assistant professor in the same department, and colleagues at BCM describe how a...

2012-01-18 15:11:58

New Findings Could Influence Design of Future Diabetes Treatments Using a blend of technologies, scientists from the Florida campus of The Scripps Research Institute have painted a new picture of how biochemical information can be transmitted through the modification of a protein. Previously, scientists believed that during the pairing of proteins and their binding partners (“ligands”), proteins modified their shape while ligands remained stable. The new study shows this...

2012-01-10 23:40:04

New findings could influence design of future diabetes treatments Using a blend of technologies, scientists from the Florida campus of The Scripps Research Institute have painted a new picture of how biochemical information can be transmitted through the modification of a protein. Previously, scientists believed that during the pairing of proteins and their binding partners ("ligands"), proteins modified their shape while ligands remained stable. The new study shows this one-size-fits-all...

2011-10-06 13:13:26

Thomas Jefferson University researchers uncover how two nuclear receptors -- EcR/Usp and E75A -- work against each other during Drosophila metamorphosis Growing up just got more complicated. Thomas Jefferson University biochemistry researchers have shown for the first time that the receptor for a major insect molting hormone doesn't activate and repress genes as once thought. In fact, it only activates genes, and it is out-competed by a heme-binding receptor to repress the same genes...

2011-09-06 22:51:08

Findings show how form controls function in sought-after therapeutic target In a joint study, scientists from the California and Florida campuses of The Scripps Research Institute have shown that changes in a protein's structure can change its signaling function and they have pinpointed the precise regions where those changes take place. The new findings could help provide a much clearer picture of potential drugs that would be both effective and highly specific in their biological...

2011-09-01 13:00:00

Promega and Puracyp team up to provide all-inclusive kits to assess critical pathways researched by drug discovery scientists. Madison, WI (PRWEB) September 01, 2011 Puracyp Inc. and Promega Corporation have teamed up to provide all-inclusive kits to assess nuclear receptor activation, P450 metabolism, and cellular toxicity during the drug development process. These whole cell assay systems will identify compounds capable of activating nuclear receptors and inducing P450 metabolism while...

2011-08-23 10:25:56

2 studies on estrogen hormones published in Molecular Endocrinology University of Houston (UH) researchers have their sights set on developing possible treatments for breast and colon cancer. In two separate, yet related, studies published in the June and August issues of the journal Molecular Endocrinology, professor Cecilia Williams and her team at the Center for Nuclear Receptors and Cell Signaling (CNRCS) explored the role of estrogen hormones in potentially treating and preventing...

2011-08-09 06:05:00

NEW YORK, and NEUILLY, France, Aug. 9, 2011 /PRNewswire/ -- Intercept Pharmaceuticals, Inc. (Intercept) and Les Laboratoires Servier (Servier) today announced that they have entered into a worldwide ex-U.S. and Japan agreement for the discovery and development of novel TGR5 agonists for the treatment of type 2 diabetes and other metabolic indications. The collaboration will leverage Intercept's drug discovery platform based on its proprietary bile acid analog chemistry and expertise...

2011-08-04 12:30:00

SAN DIEGO, Aug. 4, 2011 /PRNewswire/ -- Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (J&JPRD) announced today the publication of research that uncovered a previously unknown role for a class of molecules that could lead to future advances in immunologic medicine. The findings show a definitive link between EBI2, a G-protein-coupled receptor that controls B-cell migration, and some unexpected immunological effects of certain oxysterols. Co-authored by the...

2011-07-27 06:14:00

SAN DIEGO, July 27, 2011 /PRNewswire/ -- Visionary Pharmaceuticals, Inc., announced today that the company has raised seed round investments from a consortium of Angel Investors. The company is using the capital to develop novel small molecule retinoic acid related orphan receptor (ROR) modulators targeting TH17 T-lymphocytes for the treatment of various autoimmune disorders including rheumatoid arthritis, multiple sclerosis, psoriasis and COPD. Visionary Pharmaceuticals has created...


Word of the Day
holluschickie
  • A 'bachelor seal'; a young male seal which is prevented from mating by its herd's older males (mated bulls defending their territory).
This comes from the Russian word for 'bachelors.'
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