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Latest Nucleolus Stories

2012-07-05 23:58:43

The findings have implications for the development of new anti-cancer drugs Scientists from the Florida campus of The Scripps Research Institute have identified a series of intricate biochemical steps that lead to the successful production of proteins, the basic working units of any cell. The study, which appears in the July 6, 2012 edition of the journal Cell, sheds light on the assembly of a structure called the ribosome, a large and complex protein-producing machine inside all living...

2011-08-16 23:08:53

As part of a joint research effort with the University of Michigan, scientists from the Florida campus of The Scripps Research Institute have for the first time defined the structure of one of the cell's most basic engines, which is required for cell growth, as it assembles from its components. The study reveals a series of redundant mechanisms that assure production of these critical structures while avoiding any missteps that could lead to their destruction or to the production of incorrect...

2011-02-01 22:23:47

"Nucleolus", or small nucleus, is the term coined by early biologists for the tiny structure within the nucleus which they saw under the microscope. In this structure within the nucleus, RNA molecules and proteins are assembled to form ribosomes, the true protein factories of cells. Defective nucleoli have been implicated in several rare hereditary diseases, most recently also in neurodegenerative disorders such as Alzheimer's and Huntington's disease. Despite intense research efforts around...

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2010-07-23 10:35:25

When searching for long-lost treasure, sometimes all you need is a good flashlight. Such a "flashlight," developed at the Marine Biological Laboratory's (MBL) Josephine Bay Paul Center, has been used to illuminate a long-neglected cellular component "“ the nucleolinus "“ and confirm its role in cell division. MBL scientists Mark Alliegro and Mary Anne Alliegro, and MBL visiting investigator Jonathan Henry of University of Illinois, Urbana, present their discoveries regarding the...

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2010-03-26 12:55:00

Insights into the genomics of the human nucleolus have been revealed in a study by researchers from the University of Regensburg and the Ludwig Maximilians University in Germany and the Centro de Investigaci³n Príncipe Felipe in Spain. The research, published March 26 in the open-access journal PLoS Genetics, sheds new light on the functional organization of human genetic material. One major challenge of the post-genomic era is to understand how the genome is organized...

2008-12-15 07:00:00

SAN DIEGO, Dec. 15 /PRNewswire/ -- Cylene Pharmaceuticals today announced the initiation of a Phase II clinical trial of quarfloxin (CX-3543) in patients with carcinoid/neuroendocrine tumors (C/NET), which are malignant cancers arising from neural crest cells. "Quarfloxin (CX-3543) is a small molecule that disrupts a protein:rDNA complex that forms in the abnormal nucleoli of cancer cells, thereby selectively inducing apoptotic cell death in cancers," said Dr. William Rice, President...


Word of the Day
holluschickie
  • A 'bachelor seal'; a young male seal which is prevented from mating by its herd's older males (mated bulls defending their territory).
This comes from the Russian word for 'bachelors.'
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